Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model.
Explore this paper's citation graph
Summary
The findings identify tumor-associated macrophages and several chemotactic and angiogenic factors as potential targets for prostate cancer therapy and show the importance of extratumoral monocytes/macrophages for prostate tumor growth, angiogenesis, and extRatumoral arteriogenesis.
- Type
- article
- Published
- 2009-02-01
- Cited by
- 107
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1565999352
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44676271
Keywords
Prostate, Prostate cancer, Cancer research, Pathology, Medicine
References
- Tumour-educated macrophages promote tumour progression and metastasis
- Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms1
- Host microenvironment in breast cancer development: Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
- Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response1
- Inflammation and cancer
- Targeting vasculature in urologic tumors: Mechanistic and therapeutic significance
- Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.
- New functions for the matrix metalloproteinases in cancer progression
- Neutralizing VEGF bioactivity with a soluble chimeric VEGF‐receptor protein flt(1‐3)IgG inhibits testosterone‐stimulated prostate growth in castrated mice
- Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
- Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft.
- IL-1 is required for tumor invasiveness and angiogenesis
- Establishment and characterization of seven dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers
- Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach
- MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis.
- Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
- Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.
- The Local Injection of Peritoneal Macrophages Induces Neovascularization in Rat Ischemic Hind Limb Muscles
- Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
- Androgen‐insensitive prostate cancer cells transiently respond to castration treatment when growing in an androgen‐dependent prostate environment
Cited by
- The role of microorganisms in prostate cancer development
- Dinosaurs and ancient civilizations: reflections on the treatment of cancer.
- The War on Cancer rages on.
- Characterization of a Gene Expression Signature in Normal Rat Prostate Tissue Induced by the Presence of a Tumor Elsewhere in the Organ
- Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4. A novel strategy to reveal glioblastoma to the immune system
- Crosstalk between endothelial cells and tumor cells in head and neck cancer
- Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic
- Potential Upstream Regulators of Cannabinoid Receptor 1 Signaling in Prostate Cancer: A Bayesian Network Analysis of Data From a Tissue Microarray
- Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling.
- Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment
- Phenotypic and functional delineation of murine CX(3)CR1 monocyte-derived cells in ovarian cancer.
- Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions
- Liposomal Clodronate Treatment For Tumor Macrophage Depletion in Dogs with Soft Tissue Sarcoma
- The chemokine CCL2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast recruitment.
- Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer
- Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment.
- Macrophages and chemokines as mediators of angiogenesis
- Hijacking the vasculature in ccRCC—co-option, remodelling and angiogenesis
- Tumor Angiogenesis: MMP-Mediated Induction of Intravasation- and Metastasis-Sustaining Neovasculature
- Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.
Related papers
- Cloning and Characterization of Rat BAT3 cDNA
- EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- Anthoxanthum Mosaic Virus
- Ecological and evolutionary importance of neighbors in the grass Anthoxanthum odoratum
- European Sweet Vernal Grasses (Anthoxanthum: Poaceae, Pooideae, Aveneae): A Morphometric Taxonomical Approach
- Prostate cancers detected on repeat prostate biopsies show spatial distributions that differ from those detected on the initial biopsies
- A Cancer-Indicative microRNA Pattern in Normal Prostate Tissue
- THE EXPRESSIONS OF MITOSIS REGULATIVE FACTOR STK-15 IN PROSTATE CANCER
- CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer