Cis and trans-acting elements in somatic hypermutation

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Summary

In order to contribute to hypermutation, mismatch repair needs additional factors that are present in activated B lymphocytes but absent in the cell line investigated, and it is suggested that in highly expressed genes, the tRNA with the anticodon corresponding to a commonly used codon might become depleted.

Type
article
Published
2004-12-09
Cited by
0
References
164
Access
Open access

Keywords

Somatic hypermutation, Enhancer, Biology, Green fluorescent protein, Gene

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