Cis and trans-acting elements in somatic hypermutation
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Summary
In order to contribute to hypermutation, mismatch repair needs additional factors that are present in activated B lymphocytes but absent in the cell line investigated, and it is suggested that in highly expressed genes, the tRNA with the anticodon corresponding to a commonly used codon might become depleted.
- Type
- article
- Published
- 2004-12-09
- Cited by
- 0
- References
- 164
- Access
- Open access
- OpenAlex
- https://openalex.org/W3735936
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81056985
Keywords
Somatic hypermutation, Enhancer, Biology, Green fluorescent protein, Gene
References
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- AID: how does it aid antibody diversity?
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- GFP‐like chromoproteins as a source of far‐red fluorescent proteins
- The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes.
- Fluorescent proteins from nonbioluminescent Anthozoa species
- DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
- Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis.
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- Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
- Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line1
- Genes and antibodies.
- Endogenous Expression of Activation-Induced Cytidine Deaminase in Cell Line WEHI-2311
- Somatic hypermutation of immunoglobulin genes is linked to transcription.
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