Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells 1
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Summary
It is established that activation of STAT5 is the primary mechanism underlying both IL-7/IL-15-dependent homeostatic proliferation of naive and memory CD8+ T cells and IL-2-dependent development of CD4+CD25+ regulatory T cells.
- Type
- article
- Published
- 2003-12-01
- Cited by
- 236
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W1558462233
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25756623
Keywords
IL-2 receptor, STAT5, Cell biology, Interleukin 21, Homeostasis
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Cited by
- The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
- IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
- Homeostatic proliferation of NK cells: friend or foe in cellular immunotherapy?
- Signal transduction in CD4+CD25+ regulatory T cells: CD25 and IL-2.
- Maintenance of immune fitness during reconstitution from T cell lymphopenia by CD4-positive, CD25-positive, and Foxp3-positive regulatory T cells.
- Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
- The role of SLP-76 in the homeostasis of CD4+ T cells
- Regulation of T cell responses by the surface receptor Tim-3
- A Novel in vitro PDE7 Inhibitor Inhibits IL-2 Gene Expression in Activated T Cells and Induces Apoptosis in a B-cell Line and Monocytic Cell Line
- Mechanisms of immune evasion by gliomas.
- Forward genetic analysis of natural T regulatory cell development
- Foxp3+ regulatory T cells, immune stimulation and host defence against infection
- Design and use of constitutively active STAT5 constructs.
- Lymphocyte depletion as a barrier to immunological tolerance.
- Attenuation of IL-7 Receptor Signaling Is Not Required for Allelic Exclusion1
- Costimulation and IL-2 in natural regulatory T cell development
- B cell receptor signaling in receptor editing and leukemia
- Extrathymic generation of regulatory T cells--chances and challenges for prevention of autoimmune disease.
- A function for IL-7R for CD4+CD25+ Foxp3+ T regulatory cells
- Regulatory T cell identity: formation and maintenance
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