Endostatin signaling and regulation of endothelial cell-matrix interactions.
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Summary
Studies on the effects of endostatin on cultured endothelial cells suggest that the antimigratory and antiproliferative properties of this molecule are the major mechanisms underlying its antiangiogenic potential.
- Type
- review
- Published
- 2005-01-01
- Cited by
- 60
- References
- 148
- OpenAlex
- https://openalex.org/W1550411102
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10959249
Keywords
Endostatin, Angiogenesis, Extracellular matrix, Cell biology, Endothelial stem cell
References
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- Lack of collagen XVIII/endostatin results in eye abnormalities
- Prospective analysis of circulating endostatin levels in patients with renal cell carcinoma
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- ENDOSTATIN IN THE REGULATION OF ENDOTHELIAL CELL - MATRIX INTERACTIONS AND PERICELLULAR PROTEOLYSIS
- Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase.
- Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis.
- Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls
- Effect of antisense inhibition of Urokinase receptor on malignancy.
- Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors.
- Continuous release of endostatin from microencapsulated engineered cells for tumor therapy
- Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis.
- Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
- Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells.
- Local endostatin treatment of gliomas administered by microencapsulated producer cells
- Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
- The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen.
- Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage IV clear cell renal cancer.
- Vascular-specific growth factors and blood vessel formation
- Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.
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- Molecular biology and functions of epilysin (MMP-28)
- Comment on “Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma”
- Genetic analysis of the catalytic activity of Integrin-linked kinase (ILK) in vivo
- Regulation of extracellular matrix compounds involved in angiogenic processes in short‐ and long‐track elite runners
- Endostatin variations in childhood acute lymphoblastic leukaemia--comparison with basic fibroblast growth factor and vascular endothelial growth factor.
- Angiogenesis Inhibition Using an Oncolytic Herpes Simplex Virus Expressing Endostatin in a Murine Lung Cancer Model
- The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells
- Dermatopontin: A potential predictor for metastasis of human oral cancer
- MR Reporter Gene Imaging of Endostatin Expression and Therapy
- Basement Membrane Proteoglycans: Modulators Par Excellence of Cancer Growth and Angiogenesis
- Antiangiogenic peptides and proteins: from experimental tools to clinical drugs.
- Urinary proteomics based on capillary electrophoresis-coupled mass spectrometry in kidney disease: discovery and validation of biomarkers, and clinical application.
- Angiogenin, angiopoietin‐1, angiopoietin‐2, and endostatin serum levels in inflammatory bowel disease
- Molecular cloning, expression and purification of recombinant soluble mouse endostatin as an anti-angiogenic protein in Escherichia coli
- Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans
- Endostatin gene variation and protein levels in breast cancer susceptibility and severity
- EGFR Gene Overexpression Retained in an Invasive Xenograft Model by Solid Orthotopic Transplantation of Human Glioblastoma Multiforme Into Nude Mice
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