Reversibility of liver fibrosis
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Summary
It is shown that elastin turnover in liver injury and fibrosis is regulated by macrophages via Mmp-12 expression, activity and ratio to its inhibitor Timp-1, which leads to accumulation ofElastin in the fibrotic scars.
- Type
- article
- Published
- 2012-06-06
- Cited by
- 274
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1549253700
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14519722
Keywords
Elastin, Fibrosis, Cirrhosis, Hepatic stellate cell, Inflammation
References
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Cited by
- Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution
- Reversibility and heritability of liver fibrosis: Implications for research and therapy.
- The use of a recombinant single chain antibody in the investigation of liver fibrosis
- A new histone deacetylase inhibitor improves liverfibrosis in BDL rats through suppression of hepatic stellate cells
- Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor‐κB pathway in activated stellate cells: In vivo and in vitro studies
- Effects of small interfering RNA-mediated downregulation of the Krüppel-like factor 4 gene on collagen metabolism in human hepatic stellate cells.
- Strategies and Endpoints of Antifibrotic Drug Trials
- Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure
- Selective Apoptosis in Hepatic Stellate Cells Mediates the Antifibrotic Effect of Phenanthrenes from Dendrobium nobile
- Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.
- cAMP and Epac in the regulation of tissue fibrosis
- Antifibrotic mechanism of deferoxamine in concanavalin A induced-liver fibrosis: Impact on interferon therapy.
- Human Amniotic Epithelial Cell Transplantation Induces Markers of Alternative Macrophage Activation and Reduces Established Hepatic Fibrosis
- Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro
- MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases.
- S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis
- Dendritic Cell Regulation of Carbon Tetrachloride-induced Murine Liver Fibrosis Regression
- Using immunoproteomics to identify alpha-enolase as an autoantigen in liver fibrosis
- TIMP-1 in patients with cirrhosis: relation to liver dysfunction, portal hypertension, and hemodynamic changes
- Rationale for conducting a randomized trial to examine the efficacy of metformin in improving survival in cirrhosis: Pleiotropic effects hypothesis
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