Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke
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Summary
Whether delayed minocycline inhibits brain MMPs activated by ischemia in a model of temporary occlusion in Wistar rats is investigated and it is likely to be selective for MMP-9 at low doses.
- Type
- article
- Published
- 2006-07-17
- Cited by
- 195
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1545606956
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:626521
Keywords
Minocycline, Neuroprotection, Matrix metalloproteinase, Ischemia, Pharmacology
References
- Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry
- Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection.
- The Potential of Minocycline for Neuroprotection in Human Neurologic Disease
- Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester.
- Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
- Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1
- Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat
- Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction
- The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.
- Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice
- Neuroprotection by tetracyclines.
- A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia
- Cerebral Microvessel Responses to Focal Ischemia
- Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases
- Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.
- A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
- Metalloproteinases in biology and pathology of the nervous system
- Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94
- Suppression of human neutrophil functions by tetracyclines.
- Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia
Cited by
- Minocycline reduces oxygen–glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation
- Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model
- Microglia–blood vessel interactions: a double-edged sword in brain pathologies
- Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke
- Neural stem cell therapy for subacute and chronic ischemic stroke
- Osteopontin Expression During the Acute Immune Response Mediates Reactive Synaptogenesis and Adaptive Outcome
- Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats.
- L'activation des α-sécrétases : une nouvelle stratégie thérapeutique pour le traitement du traumatisme crânien
- Sequential Therapy with Minocycline and Candesartan Improves Long Term Recovery after Experimental Stroke
- Tratamento com minociclina e transplante intraestriatal de células mononucleares da medula óssea após acidente vascular experimental encefálico
- Oxygen-glucose deprivation (OGD) promotes microglia activation and gliogenesis but not neurogenesis in organotypic hippocampal slice culture (OHC)
- Effects of minocycline on apoptosis and angiogenesis-related protein expression in a rat model of intracerebral hemorrhage
- The role of extracellular matrix and matrix-degrading proteases in neonatal hypoxic-ischemic injury
- Involvement of matrix metalloproteinases‐2 and ‐9 in the formation of a lacuna‐like cerebral cavity
- Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage
- Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
- Metalloproteinase and stroke infarct size: role for anti‐inflammatory treatment?
- New prognostic biomarkers in patients with ischemic stroke.
- Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction
- The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage
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