Glucocorticoid-regulated gene expression during cutaneous wound repair.
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Summary
The results indicate that anti-inflammatory steroids inhibit wound repair at least in part by influencing the expression of these key regulatory molecules.
- Type
- review
- Published
- 2000-01-01
- Cited by
- 124
- References
- 73
- OpenAlex
- https://openalex.org/W1539564137
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33109826
Keywords
Proinflammatory cytokine, Wound healing, Glucocorticoid receptor, Glucocorticoid, Extracellular matrix
References
- Large induction of keratinocyte growth factor expression in the dermis during wound healing.
- A significant part of macrophage-derived growth factor consists of at least two forms of PDGF.
- Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.
- The effects of dexamethasone on in vitro collagen gene expression.
- Dexamethasone decreases the amounts of type I procollagen mRNAs in vivo and in fibroblast cell cultures.
- Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.
- The cytokine handbook
- Differential glucocorticoid regulation of collagen mRNAs in human dermal fibroblasts. Keloid-derived and fetal fibroblasts are refractory to down-regulation.
- The Molecular and Cellular Biology of Wound Repair
- The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
- Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
- Glucocorticoids inhibit the transcriptional induction of JE, a platelet-derived growth factor-inducible gene.
- Anti-inflammatory actions of glucocorticoids: molecular mechanisms.
- Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing
- Regulation of the expression of stromelysin-2 by growth factors in keratinocytes: implications for normal and impaired wound healing.
- Transforming Growth Factor‐β
- Reduced expression of PDGF and PDGF receptors during impaired wound healing.
- Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping.
- Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect
- Demonstration of 72-kDa and 92-kDa forms of type IV collagenase in human skin: variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids.
Cited by
- SEGRAs: a novel class of anti-inflammatory compounds.
- Guidelines for the treatment of arterial insufficiency ulcers
- Microgravity and the implications for wound healing
- Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
- Mechanisms of Altered Glucocorticoid Sensitivity
- Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing.
- Dynamics of cell-cell junctions in keratinocytes
- The role of nuclear hormone receptors in cutaneous wound repair
- The αvβ6 integrin plays a role in compromised epidermal wound healing
- Downregulation of human type VII collagen (COL7A1) promoter activity by dexamethasone
- Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture.
- Regulation of wound healing by growth factors and cytokines.
- Healing responses of skin and muscle in critical illness
- Enhancement of Wound Healing by Shikonin Analogue 93/637 in Normal and Impaired Healing
- Guidelines for the treatment of venous ulcers
- Expression profiles of elastase1 (NvElastaseI) and secretory leukocyte protease inhibitor (NvSLPI) during forelimb regeneration in adult Notophthalmus viridescens suggest a role in epithelial remodeling and delamination
- Nitric oxide and wound repair: role of cytokines?
- Corticosteroid-associated laminitis.
- Inflammatory Resolution: new opportunities for drug discovery
- MHC-class-II-deficiency impairs wound healing.
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