Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.
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Summary
It is shown here that the amino acids necessary for this interaction in both cases are located within the DNA binding domain, in line with the assumption, that the interaction between E2F and Sp-factors contributes to promoter-specificity.
- Type
- article
- Published
- 1999-11-12
- Cited by
- 109
- References
- 41
- OpenAlex
- https://openalex.org/W1539141311
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30216908
Keywords
E2F, Promoter, Thymidine kinase, Molecular biology, Biology
References
- Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P‐4501A1 gene.
- Mouse thymidine kinase stability in vivo and after in vitro translation.
- Functional synergy between DP‐1 and E2F‐1 in the cell cycle‐regulating transcription factor DRTF1/E2F.
- Introduction to the E2F family: protein structure and gene regulation.
- Sp1‐mediated transcriptional activation is repressed by Sp3.
- Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
- The cellular effects of E2F overexpression.
- Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction
- Cell lines derived from late embryonic stages of Drosophila melanogaster.
- Functional synergy between the transcription factor Sp1 and the estrogen receptor.
- Unique DNA binding mode of the N-terminal zinc finger of transcription factor Sp1.
- Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase.
- Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility.
- DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.
- Interaction between transcription factors Spl and YY1
- Sp3 Represses Transcription When Tethered to Promoter DNA or Targeted to Promoter Proximal RNA (*)
- The regulation of E2F by pRB-family proteins.
- Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.
- Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.
- Cell cycle-specific association of E2F with the p130 E1A-binding protein.
Cited by
- Regulation of transcription of the human MRP7 gene. Characteristics of the basal promoter and identification of tumor-derived transcripts encoding additional 5' end heterogeneity.
- Mechanisms of Cardiogenesis in Cardiovascular Progenitor Cells
- Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
- Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
- Differential effects of Sp cellular transcription factors on viral promoter activation by varicella-zoster virus (VZV) IE62 protein
- Follicular Dendritic Cells, Human Immunodeficiency Virus Type-1, And Alpha-1-Antitrypsin
- Apoptosis Gene Expression Pattern Analysis of Jurkat Cells Treated with FK506
- O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.
- Regulació del promotor de "Sp3"
- Blockade of AP‐1 activity by dominant‐negative TAM67 can abrogate the oncogenic phenotype in latent membrane protein 1‐positive human nasopharyngeal carcinoma
- EAPP: Gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest
- Unique aspects of transcriptional regulation in neurons – nuances in NFκB and Sp1-related factors
- The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1
- Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells.
- Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.
- E2F and Ras Synergize in Transcriptionally Activating p14ARF Expression
- Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1.
- Transcriptional regulation of the mouse deoxycytidine kinase: identification and functional analysis of nuclear protein binding sites at the proximal promoter.
- Autostimulation of the Epstein-Barr Virus BRLF1 Promoter Is Mediated through Consensus Sp1 and Sp3 Binding Sites
- Regulation of Sp1 by cell cycle related proteins
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