Fine Structure and Biochemical Mechanisms Underlying Nigrostriatal Inclusions and Cell Death after Proteasome Inhibition
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Summary
It is found that neurotoxicity was selective for striatal dopamine components and led to retrograde apoptosis within nigral DA cells, which developed neuronal inclusions staining for antigens of the UP system.
- Type
- article
- Published
- 2003-10-01
- Cited by
- 184
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1534557128
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12462070
Keywords
Lactacystin, Substantia nigra, Neurotoxicity, Proteasome, Programmed cell death
References
- Parkinson's disease. First of two parts.
- The latent membrane protein‐1 in Epstein‐Barr virus‐transformed lymphoblastoid cells is found with ubiquitin‐protein conjugates and heat‐shock protein 70 in lysosomes oriented around the microtubule organizing centre
- Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra.
- Ubiquitin‐mediated proteolysis: biological regulation via destruction
- Parkinson's disease. Second of two parts.
- Immunohistochemical evidence and ultrastructural compartmentalization of a new antioxidant enzyme in the rat substantia nigra
- Proteasomal inhibition leads to formation of ubiquitin/α‐synuclein‐immunoreactive inclusions in PC12 cells
- α-synuclein and cytosolic dopamine: Stabilizing a bad situation
- Impairment of the ubiquitin‐proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
- Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct
- Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
- The ubiquitin pathway in Parkinson's disease
- Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death
- Selective Blockade of mGlu5 Metabotropic Glutamate Receptors Is Protective against Methamphetamine Neurotoxicity
- Role of dopamine in the neurotoxic effects of methamphetamine.
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
- Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
- In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies.
- Aggresome‐related biogenesis of Lewy bodies
- Neuropathology of Parkinson's Disease
Cited by
- DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA (ecstasy)
- N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model.
- Neuronal inclusions in degenerative disorders Do they represent static features or a key to understand the dynamics of the disease?
- 13 The Proteasome, Protein Aggregation, and Neurodegeneration
- The role of chaperones in Parkinson's disease and prion diseases.
- Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants
- Therapeutic potential of targeting group III metabotropic glutamate receptors as a disease modifying strategy in the treatment of Parkinson's disease
- Characterisation of 20S Proteasome in Tritrichomonas foetus and Its Role during the Cell Cycle and Transformation into Endoflagellar Form
- A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132
- The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
- Proteolytic dysfunction in neurodegenerative disorders.
- Protein-handling dysfunction in Parkinson's disease.
- Parkinson's disease: animal models.
- Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease
- MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome
- Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease
- Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo
- Neuroprotective compounds and innovative therapeutic strategies for Parkinson's disease: experimental and clinical studies
- Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.
- TNFR1 Upregulation Mediates Tolerance after Brain Ischemic Preconditioning
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