Proteasomal inhibition leads to formation of ubiquitin/α‐synuclein‐immunoreactive inclusions in PC12 cells
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Summary
It is suggested that inclusion body formation and cell death may be dissociated from one another, and the two cardinal pathological features of Lewy body diseases, neuronal death and the formation of cytoplasmic ubiquitinated inclusions are replicated.
- Type
- article
- Published
- 2001-08-15
- Cited by
- 299
- References
- 39
- OpenAlex
- https://openalex.org/W1494109356
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21620897
Keywords
Lactacystin, Programmed cell death, Ubiquitin, Lewy body, Cytoplasmic inclusion
References
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- Degradation of α-Synuclein by Proteasome*
- Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex.
- Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity*
Cited by
- Role of the ubiquitin-proteasome pathway in the diagnosis of human diseases.
- Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up‐regulate iHSP70, following proteasomal inhibition
- Effect of Proteasome Inhibitors With Different Chemical Structures on the Ubiquitin–Proteasome System In Vitro
- The role of the C-terminal extension of αB-crystallin upon structure and function and the relationship with disease
- Zebrafish as a Model for the Study of Parkinson’s Disease
- Limitations of cellular models in Parkinson's disease research.
- Small-molecule inhibitors of proteasome activity.
- De la stimulation cérébrale profonde à l’étude physiopathologique de certaines formes génétiques de la Maladie de Parkinson
- Neurodegeneration in Parkinson's disease: genetics enlightens physiopathology.
- [Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].
- The role of chaperones in Parkinson's disease and prion diseases.
- ASYN and tau interaction : new drug target for neurodegenerative diseases
- Candidate genes for Parkinson disease: Lessons from pathogenesis.
- Vulnérabilité des neurones dopaminergiques dans la maladie de Parkinson : rôle des afférences excitatrices des systèmes cholinergique pédonculopontin et orexinergique hypothalamique
- Modèle progressif de la maladie de parkinson après dysfonctionnement aigu des transporteurs du glutamate dans la substance noire chez le rat.
- Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy–Lysosomal Pathway
- Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death
- Proteasomal dysfunction induced by 4‐hydroxy‐2,3‐trans‐nonenal, an end‐product of lipid peroxidation: a mechanism contributing to neurodegeneration?
- Autosomal recessive, early-onset Parkinson’s disease
- Synphilin‐1 degradation by the ubiquitin‐proteasome pathway and effects on cell survival
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