Early Block in Maturation Is Associated with Thymic Involution in Mammary Tumor-Bearing Mice1
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Summary
The findings suggest that the thymic hypocellularity seen in mammary tumor bearers is not due to a decreased level of proliferation, but, rather, to an arrest at an early stage ofThymic differentiation along with a moderate increase in apoptosis.
- Type
- article
- Published
- 2000-06-01
- Cited by
- 47
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1527495200
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27984322
Keywords
Thymic involution, Endocrinology, Propidium iodide, Apoptosis, Involution (esoterism)
References
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- Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.
- Expansion of immunoregulatory macrophages by granulocyte-macrophage colony-stimulating factor derived from a murine mammary tumor.
- Naive murine neonatal T cells undergo apoptosis in response to primary stimulation.
- Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development.
- Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.
- Developmental ages of the thymic epithelium and of the T cell precursors together determine the proportions of peripheral CD4+ cells.
- Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-gamma production in mammary tumor-bearing mice.
- Tumor necrosis factor-beta is associated with thymic apoptosis during acute rejection.
- A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
- The Functional and Histological Basis for Graft‐versus‐Host‐Induced Immunosuppression
- Decreased macrophage‐mediated cytotoxicity in mammary‐tumor‐bearing mice is related to alteration of nitric‐oxide production and/or release
- Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
- The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.
- T Cell Selection in the Thymus
- Role of interleukin‐7 in T‐cell development from hematopoietic stem cells
- The Aging Immune System: Primer and Prospectus
- Thymocyte selection: not by TCR alone
- Thymic selection: two pathways to life and two to death.
- Early steps in T cell development are affected by aging.
Cited by
- Influence of Breast Cancer on Thymic Function in Mice
- Immune dysfunction in cancer patients.
- VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.
- Иммуногистохимическая характеристика некоторых показателей тимопоэза при экспериментальном канцерогенезе
- Breaking tolerance in a mouse model of multiple myeloma by chemoimmunotherapy.
- Up-Regulation of IL-7, Stromal-Derived Factor-1α, Thymus-Expressed Chemokine, and Secondary Lymphoid Tissue Chemokine Gene Expression in the Stromal Cells in Response to Thymocyte Depletion: Implication for Thymus Reconstitution1
- Increased Regulatory versus Effector T Cell Development Is Associated with Thymus Atrophy in Mouse Models of Multiple Myeloma1
- IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte Proliferation1
- Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-γ overexpression in the tumor.
- Adipocyte and leptin accumulation in tumor-induced thymic involution.
- Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression
- Prolonged survival in mice with advanced tumors treated with syngeneic or allogeneic intra-bone marrow–bone marrow transplantation plus fetal thymus transplantation
- Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF.
- Insights into thymic involution in tumor-bearing mice
- Failure of blood-thymus barrier as a mechanism of tumor and trophoblast escape.
- Prolactin induced reversal of glucocorticoid mediated apoptosis of immature cortical thymocytes is abrogated by induction of tumor.
- Stereologic Analysis of Tissue Compartments of Gunshot-injured and Blunt-injured Spleen
- Telomere length of in vivo expanded CD4+CD25+ regulatory T-cells is preserved in cancer patients
- Immunological advantages of advanced laparoscopy.
- Culture‐differentiated CD8+ T cells acquire innate memory‐like traits and respond to a pathogen‐associated molecule
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