Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture
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Summary
The classical view and the renewed understanding of insulators as global genome organizers are discussed and the plasticity of chromatin structure and its re-organization during pluripotency and differentiation and in situations of cellular stress are discussed.
- Type
- review
- Published
- 2015-09-01
- Cited by
- 20
- References
- 93
- Access
- Open access
- OpenAlex
- https://openalex.org/W1526067277
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16904516
Keywords
Chromatin, Genome, Genomic organization, Biology, Reprogramming
References
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- Widespread rearrangement of 3D chromatin organization underlies Polycomb-mediated stress-induced silencing
Cited by
- De novo deciphering three-dimensional chromatin interaction and topological domains by wavelet transformation of epigenetic profiles
- The Impact of Rapamycin and Metformin on Genome Organization and Function in Normal Human Fibroblasts
- Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes
- Enhancers and chromatin structures: regulatory hubs in gene expression and diseases
- Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation
- Alzheimer’s disease related genes during primate evolution
- Opbp is a new architectural/insulator protein required for ribosomal gene expression
- Stressing Out: Dynamics Of Chromatin Insulator Body Formation In Eukaryotes Under Osmotic Stress
- Investigation of Enhancer-Blocking DNA Insulators in Arabidopsis thaliana
- Analysis of Chromatin Interactions of BEAF-associated Promoters Using 4C
- Chromosome territories and the global regulation of the genome
- Predicted Archaic 3D Genome Organization Reveals Genes Related to Head and Spinal Cord Separating Modern from Archaic Humans
- Profound alterations of the chromatin architecture at chromosome 11p15.5 in cells from Beckwith-Wiedemann and Silver-Russell syndromes patients
- Modulating gene regulation to treat genetic disorders
- The HPSE Gene Insulator—A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease
- A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
- Nuclear architecture and the structural basis of mitotic memory
- Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease loci
- The role of genome composition and activation in shaping the translocation landscape in health and disease
- Genomic Architecture of Nestmate Recognition Cues in the Desert Ant
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