Mitochondrial free radical generation, oxidative stress, and aging.
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Summary
Current understandings of mitochondrial DNA, RNA, and protein modifications by oxidative stress and the enzymatic removal of oxidatively damaged products by nucleases and proteases are reviewed.
- Type
- review
- Published
- 2000-08-01
- Cited by
- 3,114
- References
- 58
- OpenAlex
- https://openalex.org/W1523213544
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25739632
Keywords
Electron transport chain, Oxidative phosphorylation, Mitochondrion, Oxidative stress, Reactive oxygen species
References
- Polarographic assay and intracellular distribution of superoxide dismutase in rat liver.
- The oxidative inactivation of mitochondrial electron transport chain components and ATPase.
- Assay of metabolic superoxide production in Escherichia coli.
- Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin-free perfused rat liver.
- Detection of catalase in rat heart mitochondria.
- Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical.
- Degradation of oxidized proteins in mammalian cells
- Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.
- Oxidative stress: the paradox of aerobic life.
- Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.
- The cellular production of hydrogen peroxide.
- Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin.
- The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
- Regulation of mitochondrial respiration by adenosine diphosphate, oxygen, and nitric oxide.
- Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited.
- The role of mitochondrial glutathione in DNA base oxidation.
- Degradation of oxidatively denatured proteins in Escherichia coli.
- Polynucleotide degradation during early stage response to oxidative stress is specific to mitochondria.
- Mitochondrial decay in aging.
- Singlet oxygen induced single-strand breaks in plasmid pBR322 DNA: the enhancing effect of thiols.
Cited by
- Study of intracellular signaling pathways triggered by natural antioxidants in human endothelial cells
- A subset of newly synthesized polypeptides in mitochondria from human endothelial cells exposed to hydroperoxide stress.
- Rapid Phosphorylation of Heterogeneous Nuclear Ribonucleoprotein C1/C2 in Response to Physiologic Levels of Hydrogen Peroxide in Human Endothelial Cells*
- Superoxide in the Vascular System
- β‐Carotene cleavage products induce oxidative stress in vitro by impairing mitochondrial respiration
- Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes.
- Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress
- Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol*
- Monoamine oxydases et athérosclérose : signalisation mitogène et étude in vivo
- Mitochondrial Bound Hexokinase Activity as a Preventive Antioxidant Defense
- Testing the “garbage” accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy
- Potent therapeutic effect of melatonin on aging skin in pinealectomized rats
- Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.
- Biochemical Study on the Protective Role of Folic Acid in Rabbits Treated with Chromium (VI)
- Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells
- Mitochondrial DNA damage and its potential role in retinal degeneration.
- Basic properties and molecular mechanisms of exogenous chemical carcinogens.
- APOPTOSIS INDUCED BY PERSISTENT SINGLE-STRAND BREAKS IN THE MITOCHONDRIAL GENOME: CRITICAL ROLE OF EXOG (5’ EXO/ENDONUCLEASE) IN THEIR REPAIR
- Mitochondrial Regulation of Cell Cycle and Proliferation
- Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
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