Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.
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Summary
Redox cycling of anthracyclines by mitochondrial NADH dehydrogenase is shown, to generate O2-, H2O2, and OH which may underlie the cardiotoxicity of these antitumor agents.
- Type
- article
- Published
- 1986-03-05
- Cited by
- 615
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1585518597
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20110024
Keywords
Semiquinone, Daunorubicin, Chemistry, Submitochondrial particle, Rotenone
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