Phosphoproteomic Analysis of Cell-Based Resistance to BRAF Inhibitor Therapy in Melanoma
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Summary
The abundance of phosphopeptides with sites that function in cytoskeletal regulation, GTP/GDP exchange, protein kinase C, IGF signaling, and melanosome maturation were highly divergent after transition to a drug resistant phenotype.
- Type
- article
- Published
- 2015-05-15
- Cited by
- 31
- References
- 85
- Access
- Open access
- OpenAlex
- https://openalex.org/W1515041413
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8926998
Keywords
Kinase, Proteome, Biology, Phosphorylation, Melanoma
References
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- The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
- Phosphorylation of Ser‐3 of cofilin regulates its essential function on actin
- An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1
- The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
- Melanoma Cells Revive an Embryonic Transcriptional Network to Dictate Phenotypic Heterogeneity
- Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
- Melanosome‐autonomous regulation of size and number: the OA1 receptor sustains PMEL expression
- Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome.
- Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration
- Resistance to cisplatin‐induced cell death conferred by the activity of organic anion transporting polypeptides (OATP) in human melanoma cells
- RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
- MEK1 mutations confer resistance to MEK and B-RAF inhibition
- Phosphorylation of the cation-independent mannose 6-phosphate receptor is closely associated with its exit from the trans-Golgi network
- Activation of the epileptic focus during intracarotid amobarbital test. Electrocorticographic registration via subdural electrodes.
- ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.
- ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination
Cited by
- Editorial: Cellular and Phenotypic Plasticity in Cancer
- Proteomics approaches to understanding mitogen-activated protein kinase inhibitor resistance in melanoma
- Proteomics: An Indispensable Tool for Novel Biomarker Identification in Melanoma
- A compendium of ERK targets
- Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib
- Proteomics and phosphoproteomics in precision medicine: applications and challenges
- Diverse Mechanisms of BRAF Inhibitor Resistance in Melanoma Identified in Clinical and Preclinical Studies
- Proteomic identification of a marker signature for MAPKi resistance in melanoma
- Analyze and Identify Peiminine Target EGFR Improve Lung Function and Alleviate Pulmonary Fibrosis to Prevent Exacerbation of Chronic Obstructive Pulmonary Disease by Phosphoproteomics Analysis
- Global view of the RAF-MEK-ERK module and its immediate downstream effectors
- In Silico Tools and Phosphoproteomic Software Exclusives
- The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives
- MiR-429-5p attenuates the migration and invasion of malignant melanoma by targeting LIMK1.
- Bad Neighborhood: Fibrotic Stroma as a New Player in Melanoma Resistance to Targeted Therapies
- Proteomics pipeline for phosphoenrichment and its application on a human melanoma cell model.
- Investigation of cancer drug resistance mechanisms by phosphoproteomics.
- Phosphoproteomic strategies in cancer research: a minireview.
- Mechanisms of Acquired BRAF Inhibitor Resistance in Melanoma: A Systematic Review
- Analysis of Amino Acid Variants in Malignant Melanoma Cells Resistant to BRAF inhibition
- The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction
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