A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells.
Explore this paper's citation graph
Summary
It is demonstrated, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo.
- Type
- article
- Published
- 1999-02-01
- Cited by
- 296
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W1513672361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36990295
Keywords
Biology, Immune system, Transgene, CD8, Immunology
References
- In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation.
- IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
- A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
- IL-10: a novel cytotoxic T cell differentiation factor.
- IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.
- A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.
- Quantitative PCR: validation of the use of a multispecific internal control
- Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
- Interleukin‐10 Inhibits Antimicrobial Activity Against Leishmania major in Murine Macrophages
- Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.
- Interleukin 10 pretreatment protects target cells from tumor- and allo- specific cytotoxic T cells and downregulates HLA class I expression
- Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures.
- EFFECTS OF EXOGENOUS INTERLEUKIN‐10 IN A MURINE MODEL OF GRAFT‐VERSUS-HOST DISEASE TO MINOR HISTOCOMPATIBILITY ANTIGENS
- Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones.
- Selective regulation of ICAM‐1 and major histocompatibility complex class I and II molecule expression on epidermal Langerhans cells by some of the cytokines released by keratinocytes and T cells
- Two types of mouse helper T-cell clone Implications for immune regulation.
- Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes
- Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples
- Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression
- Administration of interleukin‐10 abolishes innate resistance to Listeria monocytogenes
Cited by
- Suppression of host resistance to Listeria monocytogenes by acute cold/restraint stress: lack of direct IL-6 involvement.
- Increased Apoptosis of CD20+ IgA+ B Cells is the Basis for IgA Deficiency: The Molecular Mechanism for Correction In Vitro by IL-10 and CD40L
- Mechanisms of immune dysfunction in renal cell carcinoma.
- The impaired Th1 immune response of C3HeB/FeJ mice infected with Leishmania amazonensis: lessons learned from immunotherapy and vaccines
- Desenvolvimento de melanoma em animais selecionados pela intensidade de resposta inflamatória aguda (Airmax/Airmin): caracterização das células Natural Killer, NKT, Treg e perfil de citocinas
- Analysis of human B cell response to recombinant Leishmania LPG3.
- The Role of IL-10 in Promoting Disease Progression in Leishmaniasis1
- Comparative Analysis of T Lymphocytes Recovered from the Lungs of Mice Genetically Susceptible, Resistant, and Hyperresistant to Mycobacterium tuberculosis-Triggered Disease1
- Proinflammatory Effects of IL-10 During Human Endotoxemia1
- The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis
- IL-10 Underlies Distinct Susceptibility of BALB/c and C57BL/6 Mice to Mycobacterium avium Infection and Influences Efficacy of Antibiotic Therapy1
- Expression of Mig (Monokine Induced by Interferon-γ) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System1
- IL-10 signaling in dendritic cells attenuates anti-Leishmania major immunity without affecting protective memory responses.
- A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages1
- Distinct Roles for IL-4 and IL-10 in Regulating T2 Immunity during Allergic Bronchopulmonary Mycosis1
- Cutting Edge: IL-10-Producing CD4+ T Cells Mediate Tumor Rejection1
- IL-10: The Master Regulator of Immunity to Infection
- IL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4+ T cells and promoting CTL persistence in a murine model of plasmacytoma
- The role of IL-27 in the induction of anti-tumor cytotoxic T lymphocyte response.
- In Vivo IL-10 Gene Delivery Suppresses Airway Eosinophilia and Hyperreactivity by Down-Regulating APC Functions and Migration without Impairing the Antigen-Specific Systemic Immune Response in a Mouse Model of Allergic Airway Inflammation1
Related papers
- Early Changes in Behavior Deficits, Amyloid β-42 Deposits and MAPK Activation in Doubly Transgenic Mice Co-expressing NSE-Controlled Human Mutant PS2 and APPsw
- Development and Characterization of Thy*IκBα-SI Transgenic Mice
- SIRT1 transgenic mice show phenotypes resembling calorie restriction
- Transgenic mice: beyond the knockout.
- [Transgenic mice in basic research].
- Transgenic mice models in autoimmunity--discussion.
- In vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic mice.
- Endothelium‐specific Cre recombinase activity in flk‐1‐Cre transgenic mice
- Gene expression profile in liver of hB1F transgenic mice.
- Principles for the use of in vivo transgene techniques: overview and an introductory practical guide for the selection of tetracycline-controlled transgenic mice.