Proinflammatory Effects of IL-10 During Human Endotoxemia1
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Summary
High-dose IL-10 treatment in patients with inflammatory disorders can be associated with undesired proinflammatory effects, as reflected by increased levels of soluble granzymes.
- Type
- article
- Published
- 2000-09-01
- Cited by
- 332
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1502971607
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:316340
Keywords
Proinflammatory cytokine, Chemokine, Cytokine, Immunology, Monokine
References
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- Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes.
- Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood. Separation of LPS- and cytokine-stimulated components using anti-tumor necrosis factor and anti-IL-1 antibodies.
- A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells.
- Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.
- A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.
- Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.
- Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells.
- In vivo production and function of IL-12 p40 homodimers.
- Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.
- Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils.
- Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance?
- Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma.
- Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia.
- Preincubation of human resting T cell clones with interleukin 10 strongly enhances their ability to produce cytokines after stimulation.
- Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
- Characterization of anti-human interleukin-18 (IL-18)/interferon-gamma-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA.
- Granzymes: exogenous proteinases that induce target cell apoptosis.
- Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist
- Biological properties of interleukin 10.
Cited by
- Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines1
- Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure
- Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers.
- Acquisition of immunity to the protozoan parasite Eimeria adenoeides in turkey poults and cellular responses to infection.
- Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes
- Recombinant Human Lactoferrin Injectable Hydrogel as an Osteogenic Biomaterial
- Interleukin-10 in the Control of Tumor Immunity and Autoimmunity.
- Pro- versus anti-inflammatory cytokines: myth or reality.
- The Molecular Basis of IL-10 Function: From Receptor Structure to the Onset of Signaling
- Mechanisms of hepatotoxicity of chloroacetonitrile - an end product of water chlorination.
- Regulation of Early T Cell Activation by TNF Superfamily Members TNF and FASL: A Dissertation
- Interleukin-10: An Anti-Inflammatory Marker To Target Atherosclerotic Lesions via PEGylated Liposomes
- Interleukin-10 in Health and Disease
- Possible Intrinsic adjuvanticity of the Amb a 1 (Ambrosia artemisiifolia :Ragweed) allergen
- Molecular cytogenetics of primary cutaneous t-cell lymphomas: From cytogenetics to the identification of specific gene-level aberrations
- Therapeutic approaches in inflammatory bowel disease based on the immunopathogenesis.
- Critical Role of Kupffer Cell-Derived IL-10 for Host Defense in Septic Peritonitis1
- EFEITO DO LASER DE BAIXA POTÊNCIA (810 nM) NA TENDINITE INDUZIDA POR COLAGENASE EM TENDÃO CALCÂNEO DE RATOS
- Cytokines and chemokines in systemic and urinary tract infection by Escherichia coli
- Differences in immune responses between CMV-seronegative and -seropositive patients with myocardial ischemia and reperfusion
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