Thrombospondin‐1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia
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Summary
To evaluate the expression of thrombospondin‐1 (TSP‐1, a potent inhibitor of angiogenesis) and vascular endothelial growth factor (VEGF, an important angiogenic factor in solid tumours) in prostate cancer, and their relationship with p53 status.
- Type
- article
- Published
- 2002-02-01
- Cited by
- 85
- References
- 22
- OpenAlex
- https://openalex.org/W1512538529
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11218727
Keywords
Prostate cancer, Medicine, Vascular endothelial growth factor, Angiogenesis, Prostate
References
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- Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation.
- Topography of neovascularity in human prostate carcinoma
- Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines
- Predictors of pathologic stage in prostatic carcinoma. The role of neovascularity
- Immunohistochemical detection of thrombospondin-1 in formalin-fixed, paraffin-embedded tissue.
- Vascular endothelial growth factor (VEGF) expression in human prostate cancer: in situ and in vitro expression of VEGF by human prostate cancer cells.
- Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression.
- Vascular endothelial growth factor (VEGF) expression in prostate cancer and benign prostatic hyperplasia.
- Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.
- Comparison of microscopic vascularity in benign and malignant prostate tissue.
- The functions of thrombospondin and its involvement in physiology and pathophysiology.
- Vascular permeability factor (vascular endothelial growth factor) is strongly expressed in the normal male genital tract and is present in substantial quantities in semen.
- A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1.
- Light microscopic immunolocation of thrombospondin in human tissues.
Cited by
- A risk model for non-small cell lung cancer using clinicopathological variables, angiogenesis and oncoprotein expression.
- Mécanismes de progression des carcinomes de la prostate et recherche de nouveaux facteurs pronostiques
- Regulation of anti-angiogenic pedf through a tsp-1 - cd36 pathway in prostate cancer
- Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma
- The Role of Stroma Microenvironments in Prostate Cancer Cell Migration and Metastasis
- Alteration of HGF and TSP‐1 expression in ovarian carcinoma associated with clinical features
- PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli.
- Non‐steroidal anti‐inflammatory drugs for lower urinary tract symptoms in benign prostatic hyperplasia: systematic review and meta‐analysis of randomized controlled trials
- Thrombospondin and Vascular Endothelial Growth Factor Are Cyclically Expressed in an Inverse Pattern During Bovine Ovarian Follicle Development1
- Thrombospondin‐1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor‐related protein‐1 (LRP‐1)
- Integrative analysis of N-linked human glycoproteomic data sets reveals PTPRF ectodomain as a novel plasma biomarker candidate for prostate cancer.
- Antibody array profiling reveals serum TSP‐1 as a marker to distinguish benign from malignant prostatic disease
- Anti‐angiogenesis effect of 3′‐sulfoquinovosyl‐1′‐monoacylglycerol via upregulation of thrombospondin 1
- Increased p53 immunoreactivity in proliferative inflammatory atrophy of prostate is related to focal acute inflammation
- Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity
- Thrombospondin-1, vascular endothelial growth factor expression and microvessel density in renal cell carcinoma and their relationship with multifocality.
- Expression of thrombospondin-1 is correlated with microvessel density in prostate cancer
- The expression of vascular endothelial growth factor is associated with the risk of cancer progression after radical prostatectomy
- The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin
- Vascular endothelial growth factor (VEGF) expression in locally advanced prostate cancer: secondary analysis of radiation therapy oncology group (RTOG) 8610
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