Recognition of adenovirus E1A gene products on immortalized cell surfaces by cytotoxic T lymphocytes
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Summary
The experiments described in this report suggest that in addition to their functions within host cells, E1A gene products are important immunogenic determinants on the surfaces of adenovirus-transformed cells.
- Type
- article
- Published
- 1988-05-01
- Cited by
- 28
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1504956726
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33333717
Keywords
Cytotoxic T cell, Biology, CTL*, Transfection, Molecular biology
References
- Susceptibility of Adenovirus 2-transformed rat cell lines to natural killer (NK) cells: direct correlation between NK resistance and in vivo tumorigenesis.
- Immortalization of rat embryo fibroblasts by an adenovirus 2 mutant expressing a single functional E1a protein
- Adenovirus E1A gene induction of susceptibility to lysis by natural killer cells and activated macrophages in infected rodent cells
- Purification of a native membrane-associated adenovirus tumor antigen
- Intra- and interspecies reactivity of human and mouse natural killer (NK) cells.
- Pentapeptide nuclear localization signal in adenovirus E1a
- Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells
- Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products
- An adenovirus mutant defective in splicing RNA from early region 1A
- Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses
- A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes
- Interactions of adenovirus type 2 with rat embryo cells. Permissiveness, transformation and in vitro characteristics of adenovirus transformed rat embryo cells.
- Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line.
- Adenovirus type 12 specific cell surface antigen in transformed cells is a product of the E1b early region.
- Complete transformation by adenovirus 2 requires both E1A proteins.
- Control of Carcinogenesis: A Possible Role for the Activated Macrophage
- Promoters and heterogeneous 5' termini of the messenger RNAs of adenovirus serotype 2.
- Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.
- Product of adenovirus type 2 early gene block E1 in transformed cells elicits cytolytic response in syngeneic rats.
- A study of the oncogenicity of adenovirus type 2 transformed rat embbyo cells
Cited by
- Assessing the role of E1A in the differential oncogenicity of group A and group C human adenoviruses.
- Adenovirus E1A gene-induced tumor cell rejection through cellular sensitization to immune and nonimmune apoptotic injuries.
- Mapping of the anti-adenoviral cytotoxic T cell response mediated by HLA-A*01, -A*02, and -A*24
- Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene
- Adenovirus E1A, Not Human Papillomavirus E7, Sensitizes Tumor Cells to Lysis by Macrophages Through Nitric Oxide- and TNF-α-Dependent Mechanisms Despite Up-Regulation of 70-kDa Heat Shock Protein1
- Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes.
- Brief report: Killer cell defect and persistent immunological abnormalities in two patients with chronic active epstein‐barr virus infection
- Adenovirus type 5 E3 gene products interfere with the expression of the cytolytic T cell immunodominant E1a antigen.
- C-terminal domain of the adenovirus E1A oncogene product is required for induction of cytotoxic T lymphocytes and tumor-specific transplantation immunity.
- Dissimilar immunogenicities of human papillomavirus E7 and adenovirus E1A proteins influence primary tumor development.
- The murine cellular immune response to adenovirus type 5
- Tumor necrosis factor mediated cytolysis requires the adenovirus E1a protein but not the transformed phenotype.
- Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer
- The Role of Mouse Adenovirus Type 1 Early Region 1A in Acute and Persistent Infections in Mice
- Wild-type adenovirus type 5 transforming genes function as transdominant suppressors of oncogenesis in mutant adenovirus type 5 transformed rat embryo fibroblast cells.
- Down-regulation of human adenovirus E1a by E3 gene products: evidence for translational control of E1a by E3 14.5K and/or E3 10.4K products.
- Adenovirus E1A Oncogene Expression in Tumor Cells Enhances Killing by TNF-Related Apoptosis-Inducing Ligand (TRAIL)1
- Synergy between the Herpes Simplex Virus tk/Ganciclovir Prodrug Suicide System and the Topoisomerase I Inhibitor Topotecan
- Tumor eradication by adoptive transfer of cytotoxic T lymphocytes.
- How DNA viruses perturb functional MHC expression to alter immune recognition.
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