Type-specific Regulation of Adenylyl Cyclase
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Summary
The data suggest the feasibility of adenylyl cyclase isoform-targeted regulation of cyclic AMP signaling by pharmacological reagents, either alone or in combination.
- Type
- article
- Published
- 2001-12-21
- Cited by
- 219
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1503606784
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30264101
Keywords
Adenylyl cyclase, ADCY9, ADCY10, Gs alpha subunit, Chemistry
References
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- Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.
- A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity.
- Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.
- Evidence for a single forskolin-binding site in rat adipocyte membrane. Studies of [14,15-3H]dihydroforskolin binding and adenylate cyclase activation.
- Kinetics of "P"-site-mediated inhibition of adenylyl cyclase and the requirements for substrate.
- Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
- Catalytic mechanism and regulation of mammalian adenylyl cyclases.
- Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.
- Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
- Molecular basis for P-site inhibition of adenylyl cyclase.
- Inhibition of Adenylyl Cyclase by Acyclic Nucleoside Phosphonate Antiviral Agents*
- Cardiovascular and Adenylate Cyclase Stimulant Properties of NKH477, a Novel Water‐Soluble Forskolin Derivative
- Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536.
- Structure, Mechanism, and Regulation of Mammalian Adenylyl Cyclase*
- Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
- A separation method for the assay of adenylylcyclase, intracellular cyclic AMP, and cyclic-AMP phosphodiesterase using tritium-labeled substrates.
- Structure of the adenylyl cyclase catalytic core
- The Catalytic Mechanism of Mammalian Adenylyl Cyclase
- Immunodetection of adenylyl cyclase protein in tissues.
Cited by
- Motor Dysfunction in Type 5 Adenylyl Cyclase-null Mice*
- Capturing adenylyl cyclases as potential drug targets
- Succinate modulates Ca(2+) transient and cardiomyocyte viability through PKA-dependent pathway.
- Regulation of renin release by local and systemic factors.
- CHARACTERIZATION OF SELECTIVE INHIBITION OF ADENYLYL CYCLASE ACTIVITY BY SMALL MOLECULE INHIBITOR NKY80
- The human cannabinoid CB(1) receptor stably expressed in Chinese hamster ovary cells provides a model system to predict the pharmacological effects of cannabinoids in man
- The Roles of Phosducin-Like Protein 1 and Programmed Cell Death Protein 5 as Molecular Co-Chaperones of the Cytosolic Chaperonin Complex
- Isoform Selective Regulation of Adenylyl Cyclase by Small Molecule Inhibitors and Gbetagamma Protein
- Enhancement, Modulation and Electrophysiological Characterization of Murine Olfactory Neurons to Odorant Stimulation in Vitro
- Developmental regulation and evolution of cAMP signalling in Dictyostelium
- Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis
- Adenylyl and Guanylyl Cyclase Assays
- Dissection of GnRH receptor-G protein coupling
- Functional characterisation of phosphodiesterase 4D7 in prostate cancer
- The role of adenylyl cyclase isoform 6 in β‐adrenoceptor signalling in murine airways
- The Concise Guide to Pharmacology 2013/14: Enzymes
- Novel Modulation of Adenylyl Cyclase Type 2
- Cholinergic receptor subtypes functional regulation in spinal cord injured monoplegic rats
- Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle
- Gain-of-Function ADCY5 Mutations in Familial Dyskinesia with Facial Myokymia
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