Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function.
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Summary
This chapter reviews the current knowledge of emmprin, especially with respect to induction of MMP production in cancer, and the relative contributions of stromal versus tumor cell production of M MPs and the role of emnprin in regulating M MP production from either source need to be elaborated.
- Type
- review
- Published
- 2003-01-01
- Cited by
- 192
- References
- 95
- OpenAlex
- https://openalex.org/W1492687483
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28990005
Keywords
Basigin, Matrix metalloproteinase, Extracellular matrix, Cell biology, Stromal cell
References
- Distribution of the integral plasma membrane glycoprotein CE9 (MRC OX-47) among rat tissues and its induction by diverse stimuli of metabolic activation.
- Expression of gelatinase B and the extracellular matrix metalloproteinase inducer EMMPRIN in benign and malignant pigment cell lesions of the skin.
- Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts
- Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
- Induction of matrix metalloproteinase 9 expression in breast carcinoma cells by a soluble factor from fibroblasts
- Structure of the mouse basigin gene, a unique member of the immunoglobulin superfamily.
- EMMPRIN-mediated MMP regulation in tumor and endothelial cells
- Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain.
- Induction of fibroblast gelatinase B expression by direct contact with cell lines derived from primary tumor but not from metastases.
- Retinal dysfunction in basigin deficiency.
- Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule.
- Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.
- Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells.
- Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.
- Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions.
- Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class II antigen.
- Unavailability of CD147 leads to selective erythrocyte trapping in the spleen.
- Dissection of Protein Linkage between Keratins and Pinin, a Protein with Dual Location at Desmosome-Intermediate Filament Complex and in the Nucleus*
- Collagenase stimulation in cocultures of human fibroblasts and human tumor cells.
- Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling.
Cited by
- Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model.
- The use of proteomics techniques to identify potential markers of early stage colorectal cancer
- Importance of Hyaluronan Metabolism and Signalling in Tumour Progression
- EMMPRIN in gynecologic cancers: pathologic and therapeutic aspects
- Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential.
- Etude de l'interaction du TIMP-1 avec ses récepteurs
- Monocarboxylate transporters and heat shock proteins in domestic pigs in relation to stress and meat quality
- Immunoexpression of EGFR and EMMPRIN in a series of cases of head and neck squamous cell carcinoma.
- RNA interference targeting CD147 inhibits the invasion of human cervical squamous carcinoma cells by downregulating MMP‐9
- Biomarker Discovery and Mechanistic Studies of Prostate Cancer Using Targeted Proteomic Approaches
- Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
- Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.
- CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes
- Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction
- Charakterisierung des Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) auf Thrombozyten und Untersuchung zur funktionellen Relevanz bei der Arteriosklerose
- Sugar‐coated sperm: Unraveling the functions of the mammalian sperm glycocalyx
- Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis
- The glycosylation characteristic of hepatoma-associated antigen HAb18G/CD147 in human hepatoma cells.
- Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression
- Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts
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