Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.
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Summary
It is indicated that host-derived gelatinase A plays an important role in angiogenesis and tumor progression, suggesting the usefulness of gelatin enzyme A inhibitors for anticancer chemotherapy.
- Type
- article
- Published
- 1998-03-01
- Cited by
- 973
- References
- 20
- OpenAlex
- https://openalex.org/W1555806697
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17968219
Keywords
Lewis lung carcinoma, Angiogenesis, Gelatinase, Matrix metalloproteinase, Gelatinase A
References
- Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines.
- Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.
- The selection and characterization of an invasive variant of the B16 melanoma.
- Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells.
- The activation of human type IV collagenase proenzyme. Sequence identification of the major conversion product following organomercurial activation.
- Interstitial collagenase is required for angiogenesis in vitro.
- Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
- A matrix metalloproteinase expressed on the surface of invasive tumour cells
- Inhibition of angiogenesis by tissue inhibitor of metalloproteinase
- Metastatic potential correlates with enzymatic degradation of basement membrane collagen
- Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity
- Identification of an inhibitor of neovascularization from cartilage.
- Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth
- Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.
- Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
- Differences in the repertoires of basement membrane degrading enzymes in two carcinoma sublines with distinct patterns of site-selective metastasis.
- Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3
- Quantification of tumour‐induced angiogenesis by image analysis
Cited by
- Biological considerations in lung cancer.
- Detection of gelatinase B activity in serum of gastric cancer patients.
- Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for angiogenesis.
- Tumour vasculature as a target for anticancer therapy.
- Matrix metalloproteinases: pro- and anti-angiogenic activities.
- Antitumor effect of a new selective matrix metalloproteinase inhibitor, MMI‐166, on experimental pancreatic cancer
- Angiogenesis and metastasis.
- Peptide Ligands for the Fibronectin Type II Modules of Matrix Metalloproteinase 2 (MMP-2)*
- Matrix metalloproteinase inhibitors (MMPIs): The beginning of phase I or the termination of phase III clinical trials
- Pro-Matrix Metalloproteinase-2 Transfection Increases Orthotopic Primary Growth and Experimental Metastasis of MDA-MB-231 Human Breast Cancer Cells in Nude Mice
- Effect of Chronic Wound Exudates and MMP-2/-9 Inhibitor on Angiogenesis In Vitro
- Making the cut: protease-mediated regulation of angiogenesis.
- Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM.
- Novel solubility‐switchable MRI agent allows the noninvasive detection of matrix metalloproteinase‐2 activity in vivo in a mouse model
- Additional parameters for the morphometry of angiogenesis and lymphangiogenesis in corneal flat mounts.
- Matrix Metalloproteinase-9 Is Essential for Ischemia-Induced Neovascularization by Modulating Bone Marrow–Derived Endothelial Progenitor Cells
- Potential applications of tissue inhibitor of metalloproteinase (TIMP) overexpression for cancer gene therapy.
- Biological role of matrix metalloproteinases: a critical balance
- Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma
- The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway
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