Where Does Parkinson Disease Pathology Begin in the Brain?
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Summary
The results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immunoreactive Lewy neurites and Lewy bodies in non-catecholaminergic neurons of the dorsal glossopharyngeus-vagus complex.
- Type
- article
- Published
- 2002-05-01
- Cited by
- 811
- References
- 111
- Access
- Open access
- OpenAlex
- https://openalex.org/W1237068170
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13799144
Keywords
Dorsal motor nucleus, Neuroscience, Anterior olfactory nucleus, Lewy body, Pathology
References
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- Cytoarchitecture of the human brain stem
- CONCENTRIC HYALIN INTRANEURONAL INCLUSIONS OF LEWY TYPE IN THE BRAINS OF ELDERLY PERSONS (50 INCIDENTAL CASES): RELATIONSHIP TO PARKINSONISM
Cited by
- Management of Parkinson’s Disease Dementia
- α‐Synuclein pathology does not predict extrapyramidal symptoms or dementia
- A critical reappraisal of current staging of Lewy-related pathology in human brain
- Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
- When does Parkinson's disease begin?
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- Alpha‐synuclein in the appendiceal mucosa of neurologically intact subjects
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- Gray matter correlates of dopaminergic degeneration in Parkinson's disease: A hybrid PET/MR study using 18F‐FP‐CIT
- Recent developments in the neuropathological diagnosis of Parkinson's disease and parkinsonism.
- RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION
- Deep brain stimulation state of the art and novel stimulation targets.
- Insights into the olfactory abilities of neurological populations. From perception to action
- Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.
- Pathology associated with sporadic Parkinson's disease--where does it end?
- Gastrointestinale Störungen beim idiopathischen Parkinson-Syndrom
- Visual attention and eye movements in Parkinson's disease
- LRRK2 genetics and expression in the Parkinsonian brain
- Oligomerization, Degradation and Aggregation Reactions and Products of Synuclein Polypeptides Related to Parkinson’s Disease
- Zur postmortalen Diagnose des idiopathischen Morbus Parkinson
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