Long-range transcriptional regulation of vertebrate developmental genes and the evolution of genome architecture
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Summary
Binformatics and zebrafish transgenesis are used to explain a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes and to analyze the arrangement of underlying gene regulation systems.
- Type
- dissertation
- Published
- 2008-09-12
- Cited by
- 0
- References
- 215
- Access
- Open access
- OpenAlex
- https://openalex.org/W1163096170
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:56097480
Keywords
Biology, Genome, Gene, Genetics, Enhancer
References
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- Endless Forms: The Evolution of Gene Regulation and Morphological Diversity
- Comparative analysis and visualization of genomic sequences using VISTA browser and associated computational tools.
- VISTA Enhancer Browser—a database of tissue-specific human enhancers
- The zebrafish genome project: sequence analysis and annotation.
- Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes
- Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase
- A molecular timescale for vertebrate evolution
- Ultraconservation identifies a small subset of extremely constrained developmental enhancers
- Multiple upstream modules regulate zebrafish myf5 expression
- Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
- Reciprocal mouse and human limb phenotypes caused by gain- and loss-of-function mutations affecting Lmbr1.
- Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineage
- A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system
- Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity
- Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells
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