Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress.
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Summary
Hampering neuron-microglia communication via the CX3CR1-CX3CL1 pathway prevents the effects of chronic unpredictable stress on microglial function, short- and long-term neuronal plasticity and depressive-like behavior.
- Type
- article
- Published
- 2016-07-01
- Cited by
- 229
- References
- 97
- Access
- Open access
- OpenAlex
- https://openalex.org/W972583108
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40575167
Keywords
CX3CR1, Microglia, CX3CL1, Neuroscience, Chronic stress
References
- Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
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- Chronic Mild Stress (CMS) in Mice: Of Anhedonia, ‘Anomalous Anxiolysis’ and Activity
- Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- Preparation of mouse brain tissue for immunoelectron microscopy
- Never-resting microglia: physiological roles in the healthy brain and pathological implications
- Peripheral and Central Mechanisms of Stress Resilience
- Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
- Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus
- Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility
- Faster, better, stronger: towards new antidepressant therapeutic strategies.
- CX3CR1 Deficiency Alters Hippocampal-Dependent Plasticity Phenomena Blunting the Effects of Enriched Environment
Cited by
- Involvement of Microglial Cells in Hypoxia-induced Pulmonary Hypertension.
- Microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus
- Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention.
- Differential Effects of Stress on Microglial Cell Activation in Male and Female Medial Prefrontal Cortex
- Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice.
- Forced swimming sabotages the morphological and synaptic maturation of newborn granule neurons and triggers a unique pro-inflammatory milieu in the hippocampus.
- Dark microglia: A new phenotype predominantly associated with pathological states
- Depression as a Glial-Based Synaptic Dysfunction
- Microglia, physiology and behavior: A brief commentary.
- Microglia across the lifespan: from origin to function in brain development, plasticity and cognition
- The force awakens: insights into the origin and formation of microglia.
- Fractalkine Attenuates Microglial Cell Activation Induced by Prenatal Stress
- Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.
- Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
- Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: Possible role of NLRP3 inflammasome pathway.
- Integrating neuroimmune systems in the neurobiology of depression
- Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa
- Microglia Ontology and Signaling
- A Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders
- Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment.
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