Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.
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Summary
The results strongly suggest that the neonatal death of jsap1-deficient mice is caused by defects in the nervous system, and the conditional deletion was a true null mutation.
- Type
- article
- Published
- 2007-12-11
- Cited by
- 14
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W819950076
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40640030
Keywords
Scaffold protein, Ablation, Neuroscience, Internal medicine, Cell biology
References
- Growth retardation and early death of β‐1, 4‐galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells
- Scaffold proteins in mammalian MAP kinase cascades.
- Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1.
- Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
- Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast.
- In Vitro Development of Mouse Embryonic Stem Cells Lacking JNK/Stress-activated Protein Kinase-associated Protein 1 (JSAP1) Scaffold Protein Revealed Its Requirement during Early Embryonic Neurogenesis*
- MAP kinase pathways in yeast: for mating and more.
- The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
- The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.
- Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.
- Mammalian MAP kinase signalling cascades
- Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system.
- A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre‐mediated recombination
- Isoforms of JSAP1 scaffold protein generated through alternative splicing.
- Expression and distribution of JNK/SAPK‐associated scaffold protein JSAP1 in developing and adult mouse brain
- MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth
- Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
- Scaffold proteins of MAP-kinase modules
- Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells.
- UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.
Cited by
- Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice
- JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis
- The role of scaffold proteins in JNK signalling
- JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration
- Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
- Ablation of the scaffold protein JLP causes reduced fertility in male mice
- Up‐regulation of c‐Jun NH2‐terminal kinase‐interacting protein 3 (JIP3) contributes to BDNF‐enhanced neurotransmitter release
- JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation*
- Molecular Mechanisms of Axon Growth and Regeneration
- A cell-autonomous role for JSAP1 and JLP in mouse cerebellar Purkinje cell survival
- JIP3 regulates neuronal radial migration by mediating TrkB axonal anterograde transport in the developing cerebral cortex.
- JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells
- A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes
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