Mechanistic Studies Of Drug Resistance Conferred By An ABC Transporter DrrAB
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Summary
The present studies revealed the existence of two novel and functionally important modules in the C-terminal domain ofDrrA that might be essential for conformational interplay between DrrA and DrrB during the catalytic cycle.
- Type
- article
- Published
- 2013-01-01
- Cited by
- 0
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W782963454
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:82448364
Keywords
ATP-binding cassette transporter, Drug, Drug resistance, Transporter, Internet privacy
References
- ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.
- Molecular mechanisms of antibacterial multidrug resistance.
- ABC proteins : from bacteria to man
- IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW,Thompson RW,et al//Proc Natl Acad Sci U S A
- The activities of the Escherichia coli MalK protein in maltose transport, regulation, and inducer exclusion can be separated by mutations
- The Q-loop of DrrA is involved in producing the closed conformation of the nucleotide binding domains and in transduction of conformational changes between DrrA and DrrB.
- The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism
- The Extreme C Terminus of the ABC Protein DrrA Contains Unique Motifs Involved in Function and Assembly of the DrrAB Complex*
- A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.
- Ion Specificity and Ionic Strength Dependence of the Osmoregulatory ABC Transporter OpuA*
- Biochemical characterization of domains in the membrane subunit DrrB that interact with the ABC subunit DrrA: identification of a conserved motif.
- Analysis of six protein structures predicted by comparative modeling techniques
- Structure and function of efflux pumps that confer resistance to drugs.
- A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle.
- Biochemical Coupling between the DrrA and DrrB Proteins of the Doxorubicin Efflux Pump of Streptomyces peucetius *
- Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis
- Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.
- Translational coupling controls expression and function of the DrrAB drug efflux pump.
- Evidence on How a Conserved Glycine in the Hinge Region of HapR Regulates Its DNA Binding Ability
- Glycine Insertion in the Hinge Region of Lactose Repressor Protein Alters DNA Binding*
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