RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo
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Summary
In vivo and in vitro results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following RSV infection that contributes to development of chronic disease.
- Type
- article
- Published
- 2015-06-01
- Cited by
- 80
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W647519093
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27372773
Keywords
Innate immune system, CD11c, Biology, Demethylase, Immunology
References
- Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria.
- Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4‐pyridine‐dicarboxylic acid as an in vitro and in cell inhibitor
- Immunoprophylaxis of respiratory syncytial virus: global experience
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- Deletion of TLR3 Alters the Pulmonary Immune Environment and Mucus Production during Respiratory Syncytial Virus Infection
- Jarid1b targets genes regulating development and is involved in neural differentiation
- A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins.
- DNA methylation: a promising landscape for immune system-related diseases.
- Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7.
- Recombinant Respiratory Syncytial Virus That Does Not Express the NS1 or M2-2 Protein Is Highly Attenuated and Immunogenic in Chimpanzees
- Immunity to and frequency of reinfection with respiratory syncytial virus.
- Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response.
- T helper cell differentiation: regulation by cis elements and epigenetics.
- Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
- RBP2‐H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells
- The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3
- Division of labor between dendritic cell subsets of the lung
- Respiratory syncytial virus pneumonia in the hospital setting: length of stay, charges, and mortality.
- A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo.
- PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis
Cited by
- Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection
- EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression
- Rapamycin increases RSV RNA levels and survival of RSV-infected dendritic cell depending on T cell contact.
- Protective and Harmful Immunity to RSV Infection.
- IL‐4Rα on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection
- Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells
- Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
- Lactobacillus johnsonii Supplementation Attenuates Respiratory Viral Infection via Metabolic Reprogramming and Immune Cell Modulation
- Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics
- Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
- Factors Affecting the Immunity to Respiratory Syncytial Virus: From Epigenetics to Microbiome
- Vitamin C and immune cell function in inflammation and cancer
- Involvement of epigenetic modification in epithelial immune responses during respiratory syncytial virus infection.
- Drosophila Histone Demethylase KDM5 regulates social behavior through immune control and gut microbiota maintanence
- Epigenetic regulation of the innate immune response to infection
- Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells
- Early Life Respiratory Syncytial Virus Infection and Asthmatic Responses.
- Sex-associated TSLP-induced Immune Alterations Following Early-life RSV Infection Leads to Enhanced Allergic Disease
- Chromatin Architecture as an Essential Determinant of Dendritic Cell Function
- Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
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