Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
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Summary
The results suggest that further development of the (-)-Beta-enantiomer of FTC is warranted as an antiviral agent for infections caused by human immunodeficiency viruses.
- Type
- article
- Published
- 1992-11-01
- Cited by
- 292
- References
- 46
- OpenAlex
- https://openalex.org/W1283296
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10048543
Keywords
Humanities, Art
References
- Mutants of feline immunodeficiency virus resistant to 3'-azido-3'-deoxythymidine
- Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).
- Sequencing end-labeled DNA with base-specific chemical cleavages.
- TheAnti-Hepatitis B VirusActivities, Cytotoxicities, andAnabolic Profiles ofthe(-) and(+)Enantiomers ofcis-5-Fluoro-1-
- Feline leukemia virus-induced immunodeficiency syndrome in cats as a model for evaluation of antiretroviral therapy.
- The determination of enzyme inhibitor constants.
- A molecular clone of HTLV-III with biological activity
- Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis
- Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity
- Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1
- Pharmacologic Studies of Nucleosides Active against the Human Immunodeficiency Virus a
- (-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro
- Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
- In situ Complexation Directs the Stereochemistry of N‐Glycosylation in the Synthesis of Oxathiolanyl and Dioxolanyl Nucleoside Analogues.
- Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate
- Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U)
- In vitro screening for antiretroviral agents against simian immunodeficiency virus (SIV).
- Anti-HIV compound assessment by two novel high capacity assays.
- Metabolism of pyrimidine L-nucleosides.
- Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase.
Cited by
- Anti-Epstein-Barr Virus (EBV) Activity of β-l-5-Iododioxolane Uracil Is Dependent on EBV Thymidine Kinase
- L-Nucleosides as chemotherapeutic agents.
- New initiatives in combination antiretroviral chemotherapy.
- Rationale for maintenance of the M184v resistance mutation in human immunodeficiency virus type 1 reverse transcriptase in treatment experienced patients.
- Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ
- Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
- Activity Profiles & Mechanisms of Resistance of 3'-Azido-2',3'-Dideoxynucleoside Analog Reverse Transcriptase Inhibitors of HIV-1
- Structure-activity-resistance relationships of novel nucleoside and nucleotide HIV-1 reverse transcriptase inhibitors
- Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics.
- Review of tenofovir-emtricitabine
- Resistance to anti-human immunodeficiency virus therapeutic agents.
- The nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors in the treatment of HIV infections (AIDS).
- TheAnti-Hepatitis B VirusActivities, Cytotoxicities, andAnabolic Profiles ofthe(-) and(+)Enantiomers ofcis-5-Fluoro-1-
- Drug Discovery Strategies and Methods
- Rat dried blood spot analysis of (R,S)-(-)- and (S,R)-(+)- enantiomers of emtricitabin on immobilized tris-(3,5-dimethylphenyl carbamate) amylose silica as a chiral stationary phase.
- Quantitation of Intracellular Triphosphate of Emtricitabine in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Patients
- A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides
- Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
- Synthesis, Antiviral Evaluation, and Computational Studies of Cyclobutane and Cyclobutene L‐Nucleoside Analogues
- Metabolism of 2′,3′-Dideoxy-2′,3′-Didehydro-β-l(−)-5-Fluorocytidine and Its Activity in Combination with Clinically Approved Anti-Human Immunodeficiency Virus β-d(+) Nucleoside Analogs In Vitro
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