Comparative transcriptome analysis of epithelial and fiber cells in newborn mouse lenses with RNA sequencing
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Summary
This is the first application of RNA-Seq to understand the transcriptional changes underlying the differentiation of epithelial cells into fiber cells in the newborn mouse lens and found that RNA- Seq identified more differentially expressed genes and correlated with RT-qPCR quantification better than previously published microarray data.
- Type
- article
- Published
- 2014-11-04
- Cited by
- 77
- References
- 128
- Access
- Open access
- OpenAlex
- https://openalex.org/W317342805
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3127933
Keywords
Biology, Lens Fiber, Transcriptome, RNA, Gene
References
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- miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease
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- iSyTE: integrated Systems Tool for Eye gene discovery.
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Cited by
- Fibrosis in the lens. Sprouty regulation of TGFß-signaling prevents lens EMT leading to cataract
- CADBURE: A generic tool to evaluate the performance of spliced aligners on RNA-Seq data
- Transcriptome Profiling of Developing Murine Lens Through RNA Sequencing.
- Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators
- RNA sequencing as a powerful tool in searching for genes influencing health and performance traits of horses
- Molecular Characterization of Mouse Lens Epithelial Cell Lines and their Suitability to Study RNA Granules and Cataract Associated Genes
- Lens Development and Crystallin Gene Expression.
- FGFR and PTEN signaling interact during lens development to regulate cell survival
- Hutterite‐type cataract maps to chromosome 6p21.32‐p21.31, cosegregates with a homozygous mutation in LEMD2, and is associated with sudden cardiac death
- Non-coding RNA profiling of the developing murine lens
- Systems Biology of Lens Development: a Paradigm for Disease Gene Discovery in the Eye
- The molecular mechanisms underlying lens fiber elongation
- Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases
- RNA Binding Proteins in Eye Development and Disease: Implication of Conserved RNA Granule Components
- Birc7: A Late Fiber Gene of the Crystalline Lens.
- Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens
- Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization
- β1-integrin controls cell fate specification in early lens development
- Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract
- Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity
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