Fibrosis in the lens. Sprouty regulation of TGFß-signaling prevents lens EMT leading to cataract
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Summary
A case is made for focusing on RTK antagonists, such as Spry, for cataract prevention and possibilities for supplanting EMT with normal fiber differentiation and thereby promoting lens regenerative processes after cataract surgery are reviewed.
- Type
- article
- Published
- 2015-05-21
- Cited by
- 110
- References
- 189
- OpenAlex
- https://openalex.org/W26003864
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29146404
Keywords
Training (meteorology), Resource (disambiguation), Business, Computer science, Geography
References
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- Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition in the Lens: A Model for Cataract Formation
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- Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye.
- Intravitreal injection of TGFbeta induces cataract in rats.
- Sprouty Is a Negative Regulator of Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Transition and Cataract
- Susceptibility to TGFbeta2-induced cataract increases with aging in the rat.
- Cataract induction in lenses cultured with transforming growth factor-beta.
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- The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation
- Inhibitory effect of TGF-beta 2 in human aqueous humor on bovine lens epithelial cell proliferation.
- Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells.
- Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation.
- Glutathione and catalase suppress TGFβ-induced cataract-related changes in cultured rat lenses and lens epithelial explants
- How cells read TGF-beta signals.
Cited by
- Intrinsic and extrinsic regulatory mechanisms are required to form and maintain a lens of the correct size and shape
- Histopathology of Subcapsular Cataract in a Patient with Atopic Dermatitis.
- The Role of Citrullination and the Type III Intermediate Filaments in Retinal Gliosis
- Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.
- MicroRNA-30a Regulation of Epithelial-Mesenchymal Transition in Diabetic Cataracts Through Targeting SNAI1
- Dickkopf‐1 inhibits Wnt3a‐induced migration and epithelial‐mesenchymal transition of human lens epithelial cells
- Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia
- Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis
- The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis
- The role of HIF-1α in the TGF-β2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells
- Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial-mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells
- MicroRNA‐508 suppresses epithelial‐mesenchymal transition, migration, and invasion of ovarian cancer cells through the MAPK1/ERK signaling pathway
- Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery
- Toll-like receptor 4 shRNA attenuates lipopolysaccharide-induced epithelial-mesenchymal transition of intrahepatic biliary epithelial cells in rats.
- Topical administration of a ROCK inhibitor prevents anterior subcapsular cataract induced by UV‐B irradiation
- JNK1/β-catenin axis regulates H2O2-induced epithelial-to-mesenchymal transition in human lens epithelial cells.
- MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.
- MicroRNA-34a inhibits epithelial-mesenchymal transition of lens epithelial cells by targeting Notch1.
- Anti-tumor Drug THZ1 Suppresses TGFβ2-mediated EMT in Lens Epithelial Cells via Notch and TGFβ/Smad Signaling Pathway
- MircoRNA-23b-3p promotes the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells by targeting Sprouty2.
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