HIV and Ribozymes.
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Summary
This chapter summarizes data from different preclinical and clinical studies conducted to evaluate the potential of ribozymes to be used in HIV-1 therapies and the different ribozyme motifs that have been modified, as well as their target sites and expression strategies.
- Type
- review
- Published
- 2015-01-01
- Cited by
- 29
- References
- 122
- OpenAlex
- https://openalex.org/W307415787
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10996213
Keywords
Ribozyme, Ligase ribozyme, Computational biology, RNA, Genetic enhancement
References
- Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme
- Ubiquitous presence of the hammerhead ribozyme motif along the tree of life.
- Directing RNase P-Mediated Cleavage of Target mRNAs by Engineered External Guide Sequences in Cultured Cells
- Use of ribozymes to inhibit gene expression.
- Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.
- Adenovirus VAI‐RNA regulates gene expression by controlling stability of ribosome‐bound RNAs.
- Toward a durable treatment of HIV-1 infection using RNA interference.
- Inhibition of human immunodeficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34+ cells from HIV-1-infected donors using retroviral vectors containing anti-HIV-1 genes.
- The Ribosome Is a Ribozyme
- Transcription of HIV: Tat and cellular chromatin.
- Multiple cis-acting elements are required for RNA polymerase III transcription of the gene encoding H1 RNA, the RNA component of human RNase P.
- Intracellular Susceptibility to Ribozymes in a Tethered Substrate—Ribozyme Provirus Model Is Not Predicted by Secondary Structures of Human Immunodeficiency Virus Type 1 RNAs in Vitro
- A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1
- Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
- Inhibition of HIV-1 replication by RNA targeted against the LTR region
- A Novel Ribozyme-Based Prophylaxis Inhibits Influenza A Virus Replication and Protects from Severe Disease
- A site-specific self-cleavage reaction performed by a novel RNA in Neurospora mitochondria.
- In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1.
- Long‐term survival and concomitant gene expression of ribozyme‐transduced CD4+ T‐lymphocytes in HIV‐infected patients
- Therapeutic applications of ribozymes and riboswitches.
Cited by
- Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes
- Effective Inhibition of HIV-1 Production by Short Hairpin RNAs and Small Interfering RNAs Targeting a Highly Conserved Site in HIV-1 Gag RNA Is Optimized by Evaluating Alternative Length Formats
- Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat
- Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy.
- Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage
- RNA Interference Therapies for an HIV-1 Functional Cure
- The Expanding Therapeutic Perspective of CCR5 Blockade
- The Chern‐Simons Current in Systems of DNA‐RNA Transcriptions
- Therapeutic Potential of Anti-HIV RNA-loaded Exosomes.
- Human Immunodeficiency Virus Infection, Treatments, and Therapy: Effect of the CCR5 Mutation
- Intracellular selection of trans-cleaving hammerhead ribozymes
- Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection
- Small RNAs to treat human immunodeficiency virus type 1 infection by gene therapy.
- A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy
- Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology
- A Discovery with Potential to Revitalize Hammerhead Ribozyme Therapeutics for Treatment of Inherited Retinal Degenerations
- Targeted immuno-antiretroviral HIV therapeutic approach to provide dual protection and boosts cellular immunity: A proof-of-concept study
- HIV Gene Therapy: An Update
- Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses
- CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair
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