Trichostatin A specifically stimulates gonadotropin FSHβ gene expression in gonadotroph LβT2 cells.
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Summary
Findings demonstrate that TSA specifically increases FSHβ subunit gene expression with a concomitant increase in whole cell histone acetylation, which suggests that the mechanisms of TSA and GnRH-induced gonadotropin sub unit gene expression are entirely distinct.
- Type
- article
- Published
- 2014-01-01
- Cited by
- 9
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W306449215
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21287423
Keywords
Trichostatin A, Histone deacetylase, Gene expression, Chemistry, Biology
References
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- Dopamine D(2) receptor expression and regulation of gonadotropin alpha-subunit gene in clonal gonadotroph LbetaT2 cells.
- Genetics of human hypogonadotropic hypogonadism.
- The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin.
- Role of GHF-1 in the Regulation of the Rat Growth Hormone Gene Promoter by Thyroid Hormone and Retinoic Acid Receptors*
- Clinical development of histone deacetylase inhibitors as anticancer agents.
Cited by
- Retinoic acid and retinaldehyde dehydrogenase are not involved in the specific induction of the follicle-stimulating hormone β subunit by trichostatin A, a selective inhibitor of histone deacetylase.
- Multifaceted Targeting of the Chromatin Mediates Gonadotropin-Releasing Hormone Effects on Gene Expression in the Gonadotrope
- HDAC inhibitors impair Fshb subunit expression in murine gonadotrope cells.
- Unravelling the role of epigenetics in reproductive adaptations to early-life environment
- The role of the hypothalamus and pituitary epigenomes in central activation of the reproductive axis at puberty.
- FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis
- Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion
- Proliferating primary pituitary cells as a model for studying regulation of gonadotrope chromatin and gene expression.
- Phosphorylation of Neurofilament Light Chain in the VLO Is Correlated with Morphine-Induced Behavioral Sensitization in Rats
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