Heterogeneity of AtT-20 cell glucocorticoid binding sites: evidence for a membrane receptor.
Explore this paper's citation graph
Summary
The affinity and specificity of these sites for the natural ligand, corticosterone, suggest that they play an important role in the subcellular mechanism of glucocorticoid action.
- Type
- article
- Published
- 1979-01-01
- Cited by
- 22
- References
- 19
- OpenAlex
- https://openalex.org/W304121671
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43820058
Keywords
Glucocorticoid, Glucocorticoid receptor, Cytosol, Corticosterone, Receptor
References
- Mammalian membrane marker enzymes: sensitive assay for 5'-nucleotidase and assay for mammalian 2',3'-cyclic-nucleotide-3'-phosphohydrolase.
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
- Progesterone receptor components: identification of subunits binding to the target-cell genome.
- Variants of HTC cells with low tyrosine aminotransferinase inducibility and apparently normal glucorticoid receptors.
- Relation Between Estrogen Inhibitory Activity and Binding to Cytosol of Rabbit and Human Uterus
- Inhibition of adrenocorticotropic hormone production by glucocorticoids in mouse pituitary tumor cells.
- Specific binding sites for natural glucocorticoids in plasma membranes of rat liver.
- Evidence for glucocorticoid transport into AtT-20/D-1 cells.
- Heterogeneity of pituitary glucocorticoid binding evidence for a transcortin-like compound.
- Evidence that natural vs synthetic steroid hormones bind to physicochemically distinct cellular receptors.
- Binding of cytosol receptor-glucocorticoid complexes by isolated nuclei of glucocorticoid-responsive and nonresponsive cultured cells.
- Reversal of dexamethasone inhibition of adrenocorticotropin release in a mouse pituitary tumor cell line either by growing cells in the absence of dexamethasone or by addition of hypothalamic extract.
- Glucocorticoid binding to plasma membranes of the adenohypophysis.
- Mechanism of action of glucocorticoids.
- Placental amino acid uptake. IV. Transport microvillous membrane vesicles.
- [116] Sodium and potassium-stimulated ATPase
Cited by
- Sensitivity of photoreceptors to elevated levels of cGMP in the human retina.
- Functions of the Mineralocorticoid Receptor in the Hippocampus.
- Reproductive Processes and Contraception
- Glucocorticoid-regulated crosstalk between arachidonic acid and endocannabinoid biochemical pathways coordinates cognitive-, neuroimmune-, and energy homeostasis-related adaptations to stress.
- Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.
- New insights regarding glucocorticoids, stress and gonadotropin suppression.
- [3H]corticosterone binding in the caudate-putamen.
- An alternative approach to the quantitation of glucocorticoid-receptor complexes in the nuclei of lymphoid cells.
- The relationship between glucocorticoid biopotency and receptor binding in the AtT-20 cell.
- Evidence for Specific Glucocorticoid Binding Sites on the Cell Membrane by Fluorescence Correlation Spectroscopy
- The effects of corticotropin-releasing factor on adrenocorticotropin secretion from perifused pituitaries in vitro: rapid inhibition by glucocorticoids.
- Solubilization and pharmacological characterization of a glucocorticoid membrane receptor from an amphibian brain.
- The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.
- Membrane receptors for steroid hormones: Signal transduction and physiological significance
- G-protein-coupled glucocorticoid receptors on the pituitary cell membrane
- Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism
- Partial purification and biochemical characterization of a membrane glucocorticoid receptor from an amphibian brain.
- Characterization of glucocorticoid receptors bound with corticosterone.
- Steroid regulation of prostaglandin dehydrogenase in human fetal membranes and placenta in relation to the onset of parturition
- Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has signifi cant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and diff erential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.
Related papers
- Structural classification of steroid-binding sites on proteins by coarse-grained atomic environment and its correlation with their biological function.
- Molecular mechanism of steroid hormone action during aging. A review.
- Progression to steroid insensitivity can occur irrespective of the presence of functional steroid receptors.
- Prolonged influence of a single neonatal steroid (dexamethasone) treatment on thymocytic steroid binding.
- ENDOCRINE DISRUPTING CHEMICALS ALTER STEROID TRANSPORT PROTEINS AND STEROID FREE AND BOUND FRACTIONS
- Naturally produced steroid hormones and their release into the environment
- Binding of hydrocortisone to rat liver histones.
- A NEW METHOD FOR THE CHARACTERIZATION OF THE ANDROGEN RECEPTORS BY USE OF A STEROID ANTIBODY
- Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review