Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells.
Explore this paper's citation graph
Summary
The is vitro and in situ results demonstrate that tumor cells not only facilitate but also have the ability to modulate connective tissue cell responsiveness to PDGF-AB/BB in a paracrine fashion, through direct cell-cell interactions in human colorectal adenocarcinoma.
- Type
- article
- Published
- 1997-08-01
- Cited by
- 70
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W261406519
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9012773
Keywords
Platelet-derived growth factor receptor, Platelet-derived growth factor, Stromal cell, Growth factor, Biology
References
- Monoclonal antibody PAL-E specific for endothelium.
- First steps of tumor-related angiogenesis.
- Pericytes as collagen-producing cells in excessive dermal scarring.
- Tissue polypeptide antigen (TPA) is related to the non‐epidermal keratins 8, 18 and 19 typical of simple and non‐squamous epithelia: re‐evaluation of a human tumor marker.
- Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma.
- Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts.
- Platelet-derived growth factor indirectly stimulates angiogenesis in vitro.
- Subunit structure of a laminin-binding integrin and localization of its binding site on laminin.
- Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand.
- Two different subunits associate to create isoform-specific platelet-derived growth factor receptors.
- Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.
- Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.
- Platelet-derived growth factor receptor signals.
- Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.
- Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.
- Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.
- Platelet-derived growth factor in autocrine transformation.
- Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
- cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules
- Epithelial component of host-tumor interactions in the orthotopic site preference of a mouse mammary tumor.
Cited by
- Oncogenic derivatives of platelet-derived growth factor receptors.
- Paracrine and autocrine functions of PDGF in malignant disease.
- Design of Oligosaccharide Libraries to Characterize Heparan Sulfate – Protein Interactions
- Inhibition of PDGF receptor signaling in tumor stroma : effects on interstitial hypertension, drug uptake and therapeutic response.
- Platelet-derived growth factor in acute and chronic renal allograft rejection
- Involvement of platelet-derived growth factor in disease: development of specific antagonists.
- Analyses of Akt and PDGF receptor expression and activation in human tumors
- Expression and characterization of VEGF receptors: their use in drug discovery
- Clinical Application of Growth Factors and Cytokines in Wound Healing
- PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
- Novel activity of acriflavine against colorectal cancer tumor cells
- Two different PDGF beta-receptor cohorts in human pericytes mediate distinct biological endpoints.
- Rationale for the development of IMC‐3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet‐derived growth factor receptor α
- The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24.
- Interference with TGF‐β1 and ‐β3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma
- Bone and wound healing augmentation with platelet-rich plasma.
- The current role of angiogenesis inhibitors in the treatment of renal cell carcinoma.
- Heparin Amplifies Platelet-derived Growth Factor (PDGF)- BB-induced PDGF α-Receptor but Not PDGF β-Receptor Tyrosine Phosphorylation in Heparan Sulfate-deficient Cells
- Receptor heterodimerization: a new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer.
- Stable Expression of Angiopoietin-1 and Other Markers by Cultured Pericytes: Phenotypic Similarities to a Subpopulation of Cells in Maturing Vessels During Later Stages of Angiogenesis In Vivo
Related papers
- Interactions between the receptors for platelet-derived growth factor and epidermal growth factor
- Proliferation Versus Migration in Platelet-derived Growth Factor Signaling
- Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.
- Clonal variation in the production of a platelet-derived growth factor-like protein and expression of corresponding receptors in a human malignant glioma.
- Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts
- PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
- Paracrine signaling by Platelet Derived Growth Factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts
- Growth factor production by human thyroid carcinoma cells: abundant expression of a platelet-derived growth factor-B-like protein by a human papillary carcinoma cell line.
- TSU-68 ameliorates hepatocellular carcinoma growth by inhibiting microenvironmental platelet-derived growth factor signaling.
- Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting