A Model for p38MAPK-Induced Astrocyte Senescence
Explore this paper's citation graph
Summary
A discrete logical model for astrocyte senescence determined by the level of DNA damage (reparable or irreparable DNA strand breaks) where the kinase p38MAPK plays a central role in the regulation of senescenced cells and SASP is proposed.
- Type
- article
- Published
- 2015-05-08
- Cited by
- 44
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W224674415
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12308542
Keywords
Senescence, Phenotype, DNA damage, Biology, Cell biology
References
- CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability.
- [Transcriptional regulation of cellular senescence].
- Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
- Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity.
- Modelling the onset of senescence at the G1/S cell cycle checkpoint
- Cellular senescence: from physiology to pathology
- Astrocytes and Brain Injury
- ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes
- Senescence-messaging secretome: SMS-ing cellular stress
- Dynamical behaviour of biological regulatory networks--I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state.
- Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway
- Living on a break: cellular senescence as a DNA-damage response
- Astrocyte Senescence as a Component of Alzheimer’s Disease
- Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype*
- Stress-induced senescence in human and rodent astrocytes
- Checkpoint control and cancer
- Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
- Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes
- Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.
- Dual Growth Arrest Pathways in Astrocytes and Astrocytic Tumors in Response to Raf-1 Activation*
Cited by
- A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis.
- Cellular Senescence, Neurological Function, and Redox State
- Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation
- MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response
- Ageing Astrocytes - Implications for Motoneuron Dysfunction and Sarcopenia
- Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review
- Interaction of DCF1 with ATP1B1 induces impairment in astrocyte structural plasticity via the P38 signaling pathway
- Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease
- Brain Inflammaging: Roles of Melatonin, Circadian Clocks and Sirtuins
- An in vivo and in vitro study of stress-induced senescence in neurones and its role in neurodegeneration
- Screening Method for Identifying Toxicants Capable of Inducing Astrocyte Senescence
- The Molecular Intersection Between Senescence and Major Depression in the Elderly.
- Ageing, Cellular Senescence and Neurodegenerative Disease
- Towards the contribution of the p38MAPK pathway to the dual role of TGFβ in cancer: A boolean model approach
- Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease
- Dynamics of the feedback loops required for the phenotypic stabilization in the epithelial‐mesenchymal transition
- ATM/miR‐34a‐5p axis regulates a p21‐dependent senescence‐apoptosis switch in non‐small cell lung cancer: a Boolean model of G1/S checkpoint regulation
- Astrocyte senescence promotes glutamate toxicity in cortical neurons
- Integrative data modeling from lung and lymphatic cancer predicts functional roles for miR-34a and miR-16 in cell fate regulation
- Regulation of senescence traits by MAPKs
Related papers
- Initiation, Progression, and Genetic Manipulation of Leaf Senescence.
- Leaf senescence in rice plants: cloning and characterization of senescence up-regulated genes.
- Gene expression during leaf senescence.
- [Markers of cellular senescence].
- Convergence and divergence in gene expression profiles induced by leaf senescence and 27 senescence-promoting hormonal, pathological and environmental stress treatments.
- Heterogeneity analysis of astrocytes following spinal cord injury at single‐cell resolution
- ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction
- Activation of the DNA Damage Response by Telomere Attrition: A Passage to Cellular Senescence
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression