Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties.

Keywords

Vinca alkaloid, Vinorelbine, Vinca, Pharmacology, In vivo

References

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Cited by

• Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemiaAnna Olsson — 2005
• Methods for studying vinca alkaloid interactions with tubulin.Sharon Lobert, John J. Correia — 2007
• INHIBITION OF PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) SIGNALLING LEADS TO RESISTANCE TO CHEMOTHERAPEUTIC AGENTS IN HUMAN CANCER CELLSGail T. McDonald — 2008
• A LOCALIZED CONTROLLED DELIVERY SYSTEM UTILIZING A BLOCK COPOLYMER TO IMPROVE THE CURRENT PARADIGM OF CHEMOTHERAPYJason Olbrich — 2013
• The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.Tatiana Okouneva, Bridget T. Hill, Leslie Wilson — 2003
• Ultrasound-assisted extraction of the three terpenoid indole alkaloids vindoline, catharanthine and vinblastine from Catharanthus roseus using ionic liquid aqueous solutionsLei Yang, Han Wang, Yuangang Zu — 2011
• Drug interactions with natural products at the blood brain barrier.Gert Fricker — 2008
• Arbuscular mycorrhizal fungi and potassium bicarbonate enhance the foliar content of the vinblastine alkaloid in Catharanthus roseusClaudia Janette De la Rosa-Mera, Ronald Ferrera‐Cerrato, Alejandro Alarcón — 2011
• Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues.Lingjun Hu, Lingjun Hu, Wei‐Bin Song — 2012
• Pharmacokinetics, tissue distribution and excretion of vinflunineXiaoping Zhao, Xiaoquan Liu, Yongsheng Wang — 2006
• Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloidsSabah Hedhili, Vincent Courdavault, Nathalie Giglioli‐Guivarc’h — 2007
• Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancerQun Li, Hing L. Sham — 2002
• Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular ResponseHoward R. Mellor, Richard Callaghan — 2008
• Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogs.Weibin Song, Min Lei, Kun Zhao — 2012
• (19)F applications in drug development and imaging - a review.Dorota Bartusik‐Aebisher, David Aebisher — 2014
• Theoretical insight into the structural mechanism for the binding of vinblastine with tubulinShao‐Ming Chi, Wei Xie, Jiwei Zhang — 2015
• BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profilesWeihong Li, Yong Shao, Lihong Hu — 2007
• Vinflunine: drug safety evaluation of this novel synthetic vinca alkaloidFabio A.B. Schutz, Joaquim Bellmunt, Jonathan E. Rosenberg — 2011
• Molecular Pharmacokinetics of Catharanthus (Vinca) AlkaloidsDominique Levêque, F. Jehl — 2007
• Serine 59 Phosphorylation of αB-Crystallin Down-regulates Its Anti-apoptotic Function by Binding and Sequestering Bcl-2 in Breast Cancer Cells*Nathalie Launay, Agathe Tarze, Patrick Vicart — 2010

Related papers

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• A phase II study of vinorelbine, a new derivative of vinca alkaloid, for previously untreated advanced non-small cell lung cancer1995
• Determination of vinorelbine (Navelbine) in tumour cells by high-performance liquid chromatography.Vincent Debal, Hamid Morjani, J.-M. Millot — 1992
• [Properties of antitumor activity of vinorelbine tartrate, a new vinca alkaloid antitumor agent].Junji Kanazawa, Makoto MORIMOTO, Kenji OHMORI — 2000
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• [Myocardial infarction and vinorelbine. Report of a case].Cathérine Dubos, Julie Prévost, J.‐F. Brun — 1991
• Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients.P. Pronzato, Marco Landucci, F. Vaira — 1994
• Vinorelbine in the treatment of lymphoma.Simon Rule, M. Tighe, Stephen J. Davies — 1998