Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism.
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Summary
The results suggest that vinca alkaloids and colchicine act on solid tumours by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity.
- Type
- article
- Published
- 1991-01-01
- Cited by
- 184
- References
- 18
- OpenAlex
- https://openalex.org/W2070108397
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31354409
Keywords
Vinblastine, Colchicine, Vincristine, Necrosis, Vinca
References
- Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy.
- Endothelium‐derived nitric oxide: actions and properties
- Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents
- Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.
- Blood flow failure as a major determinant in the antitumor action of flavone acetic acid.
- Nitric oxide: biosynthesis and biological significance.
- Divergent activity of derivatives of amsacrine (m-AMSA) towards Lewis lung carcinoma and P388 leukaemia in mice.
- Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours.
- An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.
- Tumor necrosis factor (TNF).
- MICROTUBULES AS DRUG RECEPTORS: PHARMACOLOGICAL PROPERTIES OF MICROTUBULE PROTEIN *
- Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice.
- In vitro study of vascular endothelial injury by activated platelets and its prevention.
- Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.
- Treatment of retroperitoneal residual tumor after PVB chemotherapy of nonseminomatous testicular tumors
- Important role of serotonin in the antitumor effects of recombinant human tumor necrosis factor-alpha in mice.
- Experimental screening procedures and clinical predictability value.
Cited by
- Combination of vascular targeting agents with thermal or radiation therapy.
- Pharmacodynamics of tubulin and tubulin-binding agents: extending their potential beyond taxanes.
- 'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.
- Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model
- Associations Between Physical Activity and Susceptibility to Cancer
- Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
- Antiangiogenesis is produced by nontoxic doses of vinblastine.
- Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties.
- The effect of vinca alkaloids on tumour blood flow.
- Vascular targeting of solid tumours: a major 'inverse' volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas.
- Treatment of Acute Lymphoblastic Leukaemia
- Magnetic resonance imaging and the development of vascular targeted treatments for cancer.
- MECHANISTIC STUDY OF COLCHICINE’s ELECTROCHEMICAL OXIDATION
- Prostate adenocarcinoma cells release the novel proinflammatory polypeptide EMAP-II in response to stress.
- Combretastatin A4‐phosphate and its potential in veterinary oncology: a review
- Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours
- Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.
- Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models.
- Reduced tumor oxygenation by treatment with vinblastine.
- Vinflunine in the treatment of bladder cancer
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