Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.
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Summary
Evidence that drugs of abuse are powerful modulators of synaptic plasticity is reviewed, finding that dopaminergic neurons of the ventral tegmental area as well as medium spiny neurons in nucleus accumbens show enhanced excitatory synaptic strength following passive or active exposure to drugs such as cocaine and alcohol.
- Type
- review
- Published
- 2010-01-01
- Cited by
- 69
- References
- 202
- OpenAlex
- https://openalex.org/W160990658
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11136520
Keywords
Neuroscience, Ventral tegmental area, Nucleus accumbens, Synaptic plasticity, Metaplasticity
References
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Cited by
- Pre‐synaptic dopamine D3 receptor mediates cocaine‐induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways
- Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways
- Melatonin’s stimulatory effect on adult hippocampal neurogenesis in mice persists after ovariectomy
- A Novel Model of Chronic Sleep Restriction Reveals an Increase in the Perceived Incentive Reward Value of Cocaine in High Drug-Taking Rats
- Glypican Gene GPC5 Participates in the Behavioral Response to Ethanol: Evidence from Humans, Mice, and Fruit Flies
- AKT Signaling Pathway in the Nucleus Accumbens Mediates Excessive Alcohol Drinking Behaviors
- Src family kinases: modulators of neurotransmitter receptor function and behavior.
- Cocaine sensitization inhibits the hyperpolarization-activated cation current Ih and reduces cell size in dopamine neurons of the ventral tegmental area.
- Levetiracetam Has Opposite Effects on Alcohol- and Cocaine-Related Behaviors in C57BL/6J Mice
- Repeated Cocaine Treatment Enhances HIV-1 Tat-induced Cortical Excitability via Over-activation of L-type Calcium Channels
- Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning
- Drug Addiction in Pregnancy: Disease Not Moral Failure
- Enhanced Cocaine-Associated Contextual Learning in Female H/Rouen Mice Selectively Bred for Depressive-Like Behaviors: Molecular and Neuronal Correlates
- mTOR Complex 1: A Key Player in Neuroadaptations Induced by Drugs of Abuse
- Differential role of ventral tegmental area acetylcholine and N-Methyl-D-Aspartate receptors in cocaine-seeking
- Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels.
- Mesolimbic Dopamine Transients in Motivated Behaviors: Focus on Maternal Behavior
- Acute and Chronic Effects of Ethanol on Learning-Related Synaptic Plasticity
- Striatal modulation of BDNF expression using microRNA124a‐expressing lentiviral vectors impairs ethanol‐induced conditioned‐place preference and voluntary alcohol consumption
- The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration
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