Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18).
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Summary
The capacity to lyse tumor targets was ablated in hFcalphaRI transgenic/ CR3-/- mice, although binding of neutrophils to tumor cells was intact, showing a previously unrecognized importance of CR3 for hFCalphaRI-mediated antibody-dependent cellular cytotoxicity (ADCC).
- Type
- article
- Published
- 1999-06-15
- Cited by
- 77
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W110631719
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13581155
Keywords
Antibody-dependent cell-mediated cytotoxicity, Receptor, Biology, Molecular biology, Transgene
References
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