Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18).

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Summary

The capacity to lyse tumor targets was ablated in hFcalphaRI transgenic/ CR3-/- mice, although binding of neutrophils to tumor cells was intact, showing a previously unrecognized importance of CR3 for hFCalphaRI-mediated antibody-dependent cellular cytotoxicity (ADCC).

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article
Published
1999-06-15
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Keywords

Antibody-dependent cell-mediated cytotoxicity, Receptor, Biology, Molecular biology, Transgene

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