Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.
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Summary
Since the enzymatic abnormalities in both disorders share certain metabolic consequences, the conclusion has been reached that an elevated concentration of homocysteine, homocystine, or a derivative of hornocysteines is the common factor leading to arterial damage.
- Type
- article
- Published
- 1969-07-01
- Cited by
- 2,026
- References
- 12
- Access
- Open access
- OpenAlex
- https://openalex.org/W90081202
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8960278
Keywords
Arteriosclerosis, Pathogenesis, Pathology, Medicine, Internal medicine
References
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- HOMOCYSTINURIA. STUDIES OF 20 FAMILIES WITH 38 AFFECTED MEMBERS.
- A derangement in B 12 metabolism leading to homocystinemia, cystathioninemia and methylmalonic aciduria.
- Cystathioninuria from pyridoxine deficiency complicating treatment of hypercalcaemia in a cretin.
- The identification of homocystine in the urine.
- EXPERIMENTAL ATHEROSCLEROSIS IN CEBUS MONKEYS
- Homocystinuria: An Enzymatic Defect
- Metabolic Abnormalities Detected in a Survey of Mentally Backward Individuals in Northern Ireland
- Homocystinuria: A new inborn error of Metabolism associated with Mental Deficiency
- Pathological findings in homocystinuria
- Atheromatous Changes in Aorta, Carotid and Coronary Arteries of Choline-Deficient Rats.∗
Cited by
- Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis.
- Public Health Significance of Elevated Homocysteine
- Iperomocisteinemia e rischio cardiovascolare nel diabete: fantasia o realtà?
- A study of cardiovascular risk in heterozygotes for homocystinuria.
- Evaluation of cardiovascular disease markers in patients submitted to carotid artery stenting or endarterectomy
- The caput medusae of hypercoagulability.
- Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects.
- Folate and homocysteine
- Hyperhomocyst(e)inemia induces multiorgan damage
- Moderate alcohol consumption as a cardiovascular risk factor: the role of homocysteine and the need to re-explain the 'French Paradox'.
- Xanthine Oxidase‐Derived Reactive Oxygen Species Convert Flow‐Induced Arteriolar Dilation to Constriction in Hyperhomocysteinemia Possible Role of Peroxynitrite
- Obstructive sleep apnoea syndrome--an oxidative stress disorder.
- Serum homocysteine, B12 and folic acid concentration in Thai overweight and obese subjects.
- Estrogens ,homocysteine ,vasodilatation and menopause: basic mechanisms ,interactions and clinical implications
- Elevated plasma homocysteine levels in gestational diabetes mellitus
- Measurement of homocysteine thiolactone hydrolase activity using high-performance liquid chromatography with fluorescence detection and polymorphisms of paraoxonase in normal human serum.
- Metabolic disorders in the center of genetic medicine.
- Influence of age and coronary artery disease on homocysteine levels in the young old compared with the old old and the oldest old.
- Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials.
- Homocysteine and Glutathione Peroxidase-1
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