Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme.
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Summary
Investigation of AP-1-regulated gene expression in transformed cells can be used to identify the genes in the multigenic invasion programme and to validate them as targets for diagnosis or therapy.
- Type
- review
- Published
- 2000-08-01
- Cited by
- 137
- References
- 76
- OpenAlex
- https://openalex.org/W82675992
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10840832
Keywords
Activator (genetics), Gene, Biology, Regulation of gene expression, Cell
References
- Fos-transformation activates genes associated with invasion.
- Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.
- Met-HGF/SF: tumorigenesis, invasion and metastasis.
- A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.
- A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells.
- Up-regulation of lysyl oxidase in spontaneous revertants of H-ras-transformed rat fibroblasts.
- DNA methyltransferase Dnmt1 associates with histone deacetylase activity
- HGF receptor associates with the anti‐apoptotic protein BAG‐1 and prevents cell death.
- Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.
- Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue.
- Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.
- FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA
- Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle
- Regulation of matrix metalloproteinase expression in tumor invasion
- The Repertoire of Fos and Jun Proteins Expressed during the G1 Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation
- Fra-1 Induces Morphological Transformation and Increases In Vitro Invasiveness and Motility of Epithelioid Adenocarcinoma Cells
- Analysis of AP-1 function in cellular transformation pathways
- Cellular transformation and malignancy induced by ras require c-jun
- The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells.
- The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells
Cited by
- Characterization of putative regulators of the small GTPase, Rac, in Drosophila
- Rola metalotionein i kadmu w rozwoju raka piersi
- Characterization of the AP-1 and NF-kappa B transcription factors in the U-87 astrocytoma cell line
- The Progression in the Mouse Skin Carcinogenesis Model Correlates With ERK1/2 Signaling
- IL-6 and Matrix Metalloproteinase-1 Are Regulated by the Cyclin-Dependent Kinase Inhibitor p21 in Synovial Fibroblasts1
- Serum Levels of IL-1β, IL-6, TGF-β, and MMP-9 in Patients Undergoing Carotid Artery Stenting and Regulation of MMP-9 in a New In Vitro Model of THP-1 Cells Activated by Stenting
- Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
- Psoriasin interacts with Jab1 and influences breast cancer progression.
- Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1).
- Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas.
- Lentiviral-mediated short hairpin RNA silencing of APE1 suppresses hepatocellular carcinoma proliferation and migration: A potential therapeutic target for hepatoma treatment.
- Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells.
- Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation
- Epigenetic Activation of AP-1 Promotes Squamous Cell Carcinoma Metastasis
- KITENIN increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model
- Mechanisms of cancer cell invasion.
- Transcription factors control invasion: AP-1 the first among equals
- Invasion is a genetic program regulated by transcription factors.
- Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.
- Calorie restriction modulates redox-sensitive AP-1 during the aging process
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