Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.
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Summary
Results implicate EGFR in the control of hair cycle progression, and provide new information about its role in epidermal growth and differentiation, in transgenic skin keratinocytes.
- Type
- article
- Published
- 1995-11-01
- Cited by
- 271
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W73046920
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40073736
Keywords
Biology, Epidermis (zoology), Hair follicle, Humanities, Cell biology
References
- Inhibition of wool growth in merino sheep following administration of mouse epidermal growth factor and a derivative.
- Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.
- Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5′‐upstream sequences.
- Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.
- Growth modulation of mouse keratinocytes by transforming growth factors.
- Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.
- Differentiation or immune destruction: two pathways for therapy of squamous cell carcinomas with antibodies to the epidermal growth factor receptor.
- Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants
- Targeted expression of a dominant‐negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.
- Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.
- Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function.
- Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
- Immunolocalization of epidermal growth factor receptors in normal developing human skin.
- The secret life of the hair follicle.
- The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.
- Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development.
- Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth.
- Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages.
- Epidermal hyperplasia and wool follicle regression in sheep infused with epidermal growth factor.
- The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouse.
Cited by
- HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.
- Wound-healing studies in transgenic and knockout mice
- The role of epidermal growth factor receptor in inflammation and tumorgenesis
- Skin toxicities associated with epidermal growth factor receptor inhibitors
- Update on Anti-EGFR Therapy
- Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors
- Dermatologic toxicities of targeted anticancer therapies.
- The importance of ERBB receptor tyrosine kinase signaling in colorectal cancer---Implications for EGFR-targeted therapies
- Hair follicle germinative epidermal cells : a molecular study
- Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.
- Cortical map plasticity in animals and humans.
- EGF receptor signaling in prostate morphogenesis and tumorigenesis.
- Cetuximab-Associated Elongation of the Eyelashes
- Expression of the integrin-linked kinase (ILK) in mouse skin: loss of expression in suprabasal layers of the epidermis and up-regulation by erbB-2.
- Роль селективности ингибиторов тирозинкиназ в развитии побочных эффектов при терапии хронического миелолейкоза
- Pathobiology of Cancer Regimen-Related Toxicities
- Transcription Factor CTIP2 maintains hair follicle stem cell pool and contributes to altered expression of LHX2 and NFATC1
- The EGFR gene family in embryonic cell activities.
- Understanding, recognizing, and managing toxicities of targeted anticancer therapies
- Mechanisms underlying skin disorders induced by EGFR inhibitors
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