Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients.
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Summary
Three patients with hematologic relapse after bone marrow transplantation for chronic myelogenous leukemia were treated with interferon alpha and transfusion of viable donor buffy coat and had complete hematological and cytogenetic remission, which persisted 32 to 91 weeks after treatment, an example of adoptive immunotherapy without cytoreductive chemotherapy or radiotherapy in human chimeras.
- Type
- article
- Published
- 1990-12-15
- Cited by
- 881
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W44995847
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12826994
Keywords
Medicine, Chronic myelogenous leukemia, Buffy coat, Leukemia, Immunosuppression
References
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- Rh antibodies against the pretransplant red cells following Rh‐incompatible bone marrow transplantation
- Bone marrow transplantation for patients with chronic myeloid leukemia.
- Detection of specific sequences among DNA fragments separated by gel electrophoresis.
- Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation.
- A rapid banding technique for human chromosomes.
- In vivo differentiation of leukaemic blasts and effect of low dose Ara‐C in a marrow grafted patient with leukaemic relapse
- Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: importance of a graft‐versus‐leukaemia effect
- Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion.
- Disappearance of Ph1-positive cells in four patients with chronic granulocytic leukemia after chemotherapy, irradiation and marrow transplantation from an identical twin.
Cited by
- Complications de l'immunothérapie par transfusion de lymphocytes de donneur après greffe de cellules souches hématopoïétiques
- Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy
- The rate and kinetics of molecular response to donor leucocyte transfusions in chronic myeloid leukaemia patients treated for relapse after allogeneic bone marrow transplantation
- Induction of hyperacute graft-vs-host disease after donor leukocyte infusions.
- Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia.
- Effect of induced GVHD in leukemia patients relapsing after allogeneic bone marrow transplantation: single-center experience of 33 adult patients
- Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion
- A novel ‘sort-suicide’ fusion gene vector for T cell manipulation
- ‘GVHD’: graft-versus-host disease or graft-versus-Hodgkin's disease? an old acronym with new meaning
- Direct cloning of leukemia-reactive T cells from patients treated with donor lymphocyte infusion shows a relative dominance of hematopoiesis-restricted minor histocompatibility antigen HA-1 and HA-2 specific T cells
- Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation
- Adoptive immunotherapy of BCR-ABL-induced chronic myeloid leukemia-like myeloproliferative disease in a murine model.
- Antitumor Effect of Large Doses IL-2-Activated HLA Haploidentical Peripheral Blood Stem Cells on Refractory Metastatic Solid Tumor Treatment
- Donor lymphocyte infusions to treat hematologic malignancies in relapse after allogeneic blood or marrow transplantation.
- Posttransplant Administration of Cyclophosphamide and Donor Lymphocyte Infusion Induces Potent Antitumor Immunity to Solid Tumor
- Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting
- Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia.
- Donor lymphocyte infusion for BK virus hemorrhagic cystitis and nephropathy: a case report
- Designing T-cells with desired T-cell receptor make-up for immunotherapy
- Hematopoietic cell transplantation for treatment of primary immune deficiencies.
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