Direct cloning of leukemia-reactive T cells from patients treated with donor lymphocyte infusion shows a relative dominance of hematopoiesis-restricted minor histocompatibility antigen HA-1 and HA-2 specific T cells
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Summary
To clonally analyze the leukemia-reactive immune response, T cells responding to the malignancy by secreting IFNγ were isolated from peripheral blood, directly cloned, and expanded and found that 3–35% of cytotoxic T lymphocyte (CTL) clones isolated were specific for HA-1 or HA-2.
- Type
- article
- Published
- 2004-04-01
- Cited by
- 73
- References
- 51
- OpenAlex
- https://openalex.org/W14973499
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22184327
Keywords
Computer science
References
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- Designing T-cells with desired T-cell receptor make-up for immunotherapy
- Vakzinierungsversuche zur Leukämietherapie bei Patienten mit chronischer myeloischer Leukämie nach allogener Stammzelltransplantation
- Allogeneic cellular immunotherapy for chronic B-cell leukemia
- Targeting the silent minority: emerging immunotherapeutic strategies for eradication of malignant stem cells in chronic myeloid leukaemia
- Minor histocompatibility antigen DDX3Y induces HLA-DQ5-restricted T cell responses with limited TCR-Vbeta usage both in vivo and in vitro.
- Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
- Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation
- Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity.
- A Good Manufacturing Practice procedure to engineer donor virus-specific T cells into potent anti-leukemic effector cells
- Therapeutic and diagnostic applications of minor histocompatibility antigen HA-1 and HA-2 disparities in allogeneic hematopoietic stem cell transplantation: a survey of different populations.
- Effective graft depletion of MiHAg T-cell specificities and consequences for graft-versus-host disease.
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- Update on cancer vaccines
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- The relevance of minor histocompatibility antigens in solid organ transplantation
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