Effect of insulin on ketone body clearance studied by a ketone body “clamp” technique in normal man
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Summary
The data suggest that the antiketotic effect of insulin therapy results in part from an increase in peripheral ketone body disposal.
- Type
- article
- Published
- 1988-01-01
- Cited by
- 25
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W41000159
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23208321
Keywords
Ketone bodies, Insulin, Endocrinology, Internal medicine, Ketoacidosis
References
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- Determination of 14C-labelled ketone bodies by liquid-scintillation counting.
- Decreased rate of ketone-body oxidation and decreased activity of D-3-hydroxybutyrate dehydrogenase and succinyl-CoA:3-oxo-acid CoA-transferase in heart mitochondria of diabetic rats.
- Determination of total serum insulin (IRI) in insulin-treated diabetic patients
- Diabetic coma, ketoacidotic and hyperosmolar
- Alteration of the apparent Ki of carnitine palmitoyltransferase for malonyl-CoA by the diabetic state and reversal by insulin.
- Validation of a tracer technique to determine nonsteady-state ketone body turnover rates in man.
- Acetoacetate as fuel of respiration in the perfused rat heart.
- Relationship between plasma and muscle concentrations of ketone bodies and free fatty acids in fed, starved and alloxan-diabetic states.
- Ketone Body Production and Disposal in Diabetic Ketosis: A Comparison with Fasting Ketosis
- A potential pitfall in the use of isotopes to measure ketone body production.
- Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses.
- Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man.
- Inhibition of ketogenesis by ketone bodies in fasting humans.
- Human splanchnic metabolism during diabetic ketoacidosis.
- Utilization of Ketone Bodies by Adipose Tissue and Its Regulation by Carbohydrate Metabolism
- Radiochemical assay of long-chain fatty acids using 63Ni as tracer.
- The Differential Effect of Insulin in Vivo on the Peripheral Utilization of Glucose and Ketone Bodies in the Rat
- Pancreatic glucagon secretion in normal and diabetic subjects.
- Failure of glucagon to stimulate ketone body production during acute insulin deficiency or insulin replacement in man
Cited by
- Treatment of diabetic ketoacidosis in children and adolescents.
- Post-glucose load changes of plasma key metabolite and insulin concentrations during pregnancy and lactation in ewes with different susceptibility to pregnancy toxaemia.
- Impaired Glucose Tolerance is Characterized by Multiple Abnormalities in the Regulation of Intermediary Metabolism
- The Effect of Glucose and Insulin Infusion on the Fall of Ketone Bodies During Treatment of Diabetic Ketoacidosis
- The Clinical Potential of Exhaled Breath Analysis For Diabetes Mellitus
- Pregnancy impairs ketone body disposal in late gestating ewes: implications for onset of pregnancy toxaemia.
- Some Immunohormonal Changes in Experimentally Pregnant Toxemic Goats
- Acute nutritional ketosis: implications for exercise performance and metabolism
- Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men
- Noninvasive measurement of plasma glucose from exhaled breath in healthy and type 1 diabetic subjects.
- Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
- Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins
- Clinical, Biochemical and Histological Changes During Developement of Pregnancy Ketosis in Goats
- Spontaneous dissemination of DKA prevention campaign successfully launched in Nineties in Parma’s province
- Association between insulin resistance and the development of cardiovascular disease
- Breath acetone as a marker of energy balance: an exploratory study in healthy humans
- Associations between ketone bodies and fasting plasma glucose in individuals with post-pancreatitis prediabetes
- Physiology, Endocrine Hormones
- Cardiac ketone body metabolism.
- Altered Nutrient Status Reprograms Host Inflammation and Metabolic Health via Gut Microbiota
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- The relationship of a high level of serum beta-hydroxybutyrate to cause of death.
- Relationship of Blood Acetoacetate and 3-Hydroxybutyrate in Diabetes
- Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
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