The principles of MiRNA-masking antisense oligonucleotides technology.
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Summary
The miR-mask approach is a valuable supplement to the AMO technique; while AMO is indispensable for studying the overall function of an miRNA, the miR -mask might be more appropriate for study the specific outcome of regulation of the target gene by the miRNA.
- Type
- article
- Published
- 2011-01-01
- Cited by
- 102
- References
- 16
- OpenAlex
- https://openalex.org/W34714686
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11901185
Keywords
Masking (illustration), Oligonucleotide, microRNA, Computer science, Computational biology
References
- MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
- MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)*
- Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430
- MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
- Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells*
- MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation
- Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
- miR-21-mediated tumor growth
- MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
- miRNAs at the heart of the matter
- MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas.
- Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
- MicroRNAs as targets for antisense-based therapeutics
- Silencing of microRNAs in vivo with ‘antagomirs’
- Retracted: Novel approaches for gene‐specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4
- A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference
Cited by
- Epigenetics in autoimmune diseases: Pathogenesis and prospects for therapy.
- MicroRNAs in Pediatric Acute Lymphoblastic Leukemia: Small players with huge potential
- The Therapeutic Potential of MicroRNAs: Disease Modulators and Drug Targets
- Clinical application of microRNA in gastric cancer in Eastern Asian area.
- ES cells overexpressing microRNA-1 attenuate apoptosis in the injured myocardium
- MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.
- Managing microRNAs with vector-encoded decoy-type inhibitors.
- MicroRNAs in acute leukemia: from biological players to clinical contributors
- MicroRNA miR-122 as a therapeutic target for oligonucleotides and small molecules.
- miRNA-Based Therapeutic Strategies
- MicroRNAs and atrial fibrillation: mechanisms and translational potential
- MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart.
- microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases
- MicroRNAs in Rheumatoid Arthritis
- Dissecting the role of microRNAs in prostate cancer metastasis: implications for the design of novel therapeutic approaches
- Oligonucleotide analogues as modulators of the expression and function of noncoding RNAs (ncRNAs): emerging therapeutics applications.
- Targeting microRNAs to withstand cancer metastasis.
- Controlling the intracellular processes
- Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)
- The Role of MicroRNAs in Antiarrhythmic Therapy for Atrial Fibrillation.
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