Enhancers in disease: molecular basis and emerging treatment strategies.
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Summary
How enhancer disruptions have recently been implicated in congenital disorders, cancers, and common complex diseases are reviewed and the implications for diagnosis and treatment are addressed.
- Type
- article
- Published
- 2021-08-19
- Cited by
- 150
- References
- 130
- Access
- Open access
- OpenAlex
- https://openalex.org/W34420874
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:237267736
Keywords
CONTEST, Oceanography, Geology, Geography, Political science
References
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- ChromHMM: automating chromatin state discovery and characterization
- Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
- Transcriptional enhancers: functional insights and role in human disease
- Chromatin signatures of active enhancers
- Enhancer function: new insights into the regulation of tissue-specific gene expression
- Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
- A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping
- Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis
- Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence
- Suppression of inflammation by a synthetic histone mimic
- An atlas of active enhancers across human cell types and tissues
- Enhancer biology and enhanceropathies
- Bromodomain: an acetyl‐lysine binding domain
- Transcription factors: from enhancer binding to developmental control
- Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants
- Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin Interactions
- Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
- Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants
- Integrative analysis of 111 reference human epigenomes
Cited by
- GRaNIE and GRaNPA: Inference and evaluation of enhancer-mediated gene regulatory networks applied to study macrophages
- Translating osteoarthritis genetics research: challenging times ahead.
- Toward transcriptomics as a primary tool for rare disease investigation
- Epigenetics of alcohol-related liver diseases
- Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities
- Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer
- Enhancer-gene specificity in development and disease
- Analysis of the landscape of human enhancer sequences in biological databases
- 3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2
- Transfer learning identifies sequence determinants of regulatory element accessibility
- Disruption of the gene regulatory programme in neurodevelopmental disorders.
- Cross-species enhancer prediction using machine learning.
- Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
- RNetDys: identification of disease-related impaired regulatory interactions due to SNPs
- Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?
- Widespread enhancer co-activity identified by multimodal single cell analysis
- Identification of transcription factors dictating blood cell development using a bidirectional transcription network-based computational framework
- Targeted screening of genetic associations with COVID-19 susceptibility and severity
- Current challenges in understanding the role of enhancers in disease.
- Optimized high-throughput screening of non-coding variants identified from genome-wide association studies
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