Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention
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Summary
This screen represents one of the first attempts to identify chemopreventive agents using integrated criteria consisting of the inhibition of TCF/LEF, NF-κB and induction of NRF2 transcriptional activity.
- Type
- article
- Published
- 2019-04-17
- Cited by
- 10
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W30996256
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:119102109
Keywords
Abstinence, Human sexuality, Sexuality education, Sex education, Psychology
References
- The Antifungal Drug Itraconazole Inhibits Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, Trafficking, and Signaling in Endothelial Cells*
- Lowering LDL--Not Only How Low, But How Long?
- Nuclear factor-κB: its role in health and disease
- Approaches to prevention of epithelial cancer during the preneoplastic period.
- Chemoprevention: an essential approach to controlling cancer
- Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
- Fenbendazole as a Potential Anticancer Drug
- Mode of Action Studies: Basis for the Search of New Antifungal Drugs
- Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice
- Identification of stem cells in small intestine and colon by marker gene Lgr5
- Coordinate up‐regulation of low‐density lipoprotein receptor and cyclo‐oxygenase‐2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies
- APC, Signal transduction and genetic instability in colorectal cancer
- Inhibition of angiogenesis by the antifungal drug itraconazole.
- Wnt/β-catenin signaling and disease.
- The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia.
- Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins
- Lipoproteins induce expression of the early growth response gene-1 in vascular smooth muscle cells from rat.
- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
- Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
- Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors.
Cited by
- AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity.
- S-1, Oxaliplatin, Nab-paclitaxel and Itraconazole for Conversion Surgery for Advanced or Recurrent Gastric Cancer
- Artesunate Inhibits Intestinal Tumorigenesis through Inhibiting Wnt Signaling.
- High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer.
- Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet
- Symposium 6 “Researches for cancer prevention and future development”
- Theoretical basis validation and oxidative stress markers for cancer prevention clinical trials of aspirin
- Association between the gut microbiota, inflammatory factors, and colorectal cancer: evidence from Mendelian randomization analysis
- Oligonol inhibits mouse intestinal tumorigenesis through Wnt signal regulation
- Teacher positioning on the teaching of sexuality education in Life Orientation
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