Discovery and development of new antibacterial drugs: learning from experience?
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Summary
To facilitate discovery activities there must be increased understanding of the scientific problems experienced by pharmaceutical companies, coupled with addressing the current antibiotic resistance crisis so that compounds and ultimately drugs are delivered to treat the most urgent clinical challenges.
- Type
- article
- Published
- 2018-06-01
- Cited by
- 202
- References
- 34
- OpenAlex
- https://openalex.org/W29438542
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46799329
Keywords
Geology
References
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- ChloS-HRM, a novel assay to identify chloramphenicol-susceptible Escherichia coli and Klebsiella pneumoniae in Malawi
- The FICI paradigm: Correcting flaws in antimicrobial in vitro synergy screens at their inception
- Synthesis and evaluation of Quinoline-3-carbonitrile derivatives as potential antibacterial agents.
- Docking on Lipid II-A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides.
- Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies.
- Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?
- Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations
- Genetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents
- Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria.
- Methods for Detection of and Therapy for Carbapenem-Resistant Enterobacteriaceae
- Особенности противомикробной активности некоторых 5-аминометилен-2-тиоксо-4-тиазолидинонов
- Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens
- Synthesis and antimicrobial evaluation of piperic acid amides and their lower homologues
- On the persistence of lytic bacteriophages in vivo and its consequences for bacteriophage therapy
- Exploration of (3‐benzyl‐5‐hydroxyphenyl)carbamates as new antibacterial agents against Gram‐positive bacteria
- Identification of Antimicrobial Compounds from Sandwithia guyanensis-Associated Endophyte Using Molecular Network Approach
- Biotechnological, biomedical, and agronomical applications of plant protease inhibitors with high stability: A systematic review.
- Antimicrobial production by strictly anaerobic Clostridium species.
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